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Preoperative use of sestamibi scintigraphy has become commonplace and allows surgeons the option of a minimally invasive, or focused approach for their patients with primary hyperparathyroidism. Intraoperative use of the gamma probe based on sestamibi localization has not caught on due to lesser accuracy, cumbersome gamma probes, small doses of radiation exposure for patients and staff, and the greater accuracy and current confidence in intraoperative parathormone (PTH) monitoring. However, with the potential for smaller and more accurate gamma probes that truly assist in localizing abnormal parathyroid glands, the potential for cost reduction by shortening operative times, avoiding expensive PTH assays, and eliminating the need for pathologic analysis, gamma scintigraphy may yet become a viable option for many parathyroid surgeons.<\/jats:p>","DOI":"10.1007\/s00268-004-7639-2","type":"journal-article","created":{"date-parts":[[2004,11,5]],"date-time":"2004-11-05T17:17:42Z","timestamp":1099675062000},"page":"1207-1211","source":"Crossref","is-referenced-by-count":9,"title":["Technetium\u201099m 2\u2010Methoxyisobutyl isonitrile\u2010scintigraphy: Preoperative and Intraoperative Guidance for Primary Hyperparathyroidism"],"prefix":"10.1002","volume":"28","author":[{"given":"David R.","family":"Farley","sequence":"first","affiliation":[{"name":"Department of Surgery Mayo Clinic 200 First Street, SW Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,4]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1524-153X(99)80005-0"},{"key":"e_1_2_11_3_2","unstructured":"FreiROptimal approach to primary hyperparathyroidism outlined at ACS.Gen. 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