{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T12:28:49Z","timestamp":1742387329359},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2004,10,14]],"date-time":"2004-10-14T00:00:00Z","timestamp":1097712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary hyperparathyroidism (pHPT) is a rare endocrine disease in children and young adults. The widespread use of new developments in pHPT surgery (i.e., unilateral and minimally invasive approaches) is based on the assumption that the solitary adenoma is the predominant intraoperative finding, but it has not been evaluated in the subgroup of young patients. From April 1986 to December 2002, a total of 1219 patients with pHPT have been operated on in our institution. The records of 64 patients (5.3%) younger than 30 years were extracted and compared to those of the older patients. The study group (median age 25 years, range 11\u201330 years) had significantly less bone pain, fewer signs of bone demineralization, and fewer neuropsychiatric symptoms. Eleven patients had hereditary disease. We found a solitary adenoma in only 32 of the 64 juvenile patients (<jats:italic>p<\/jats:italic> &lt; 0.001), multiple gland disease in 25 patients (<jats:italic>p<\/jats:italic> &lt; 0.001), and two suspected carcinomas. No adenoma could be identified in five patients. Follow\u2010up of 54 patients after a median of 6.1 years revealed 42\u00a0normocalcemic patients, 5 hypocalcemic patients, and 7 patients with hypercalcemia. Altogether, 16 juvenile patients underwent parathyroid reoperations (25%) compared to 105 older patients (9%) (<jats:italic>p<\/jats:italic> = 0.003). Problems and difficulties with parathyroid surgery are pronounced in younger patients. The high rate of multiple gland disease requires bilateral cervical exploration as the standard procedure in pHPT patients younger than 30 years of age.<\/jats:p>","DOI":"10.1007\/s00268-004-7671-2","type":"journal-article","created":{"date-parts":[[2004,10,14]],"date-time":"2004-10-14T21:23:41Z","timestamp":1097789021000},"page":"1153-1156","source":"Crossref","is-referenced-by-count":20,"title":["Primary Hyperparathyroidism in the Young Age Group: Particularities of Diagnostic and Therapeutic Schemes"],"prefix":"10.1002","volume":"28","author":[{"given":"Kenko","family":"Cupisti","sequence":"first","affiliation":[{"name":"Department of General and Trauma Surgery University Hospital Heinrich\u2010Heine University D\u00fcsseldorf Moorenstrasse 5 40225 D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Raffel","sequence":"additional","affiliation":[{"name":"Department of General and Trauma Surgery University Hospital Heinrich\u2010Heine University D\u00fcsseldorf Moorenstrasse 5 40225 D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Dotzenrath","sequence":"additional","affiliation":[{"name":"St. Antonius Clinics Center of Endocrine Surgery Vogelsangstrasse 106 42109 Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Krausch","sequence":"additional","affiliation":[{"name":"Department of General and Trauma Surgery University Hospital Heinrich\u2010Heine University D\u00fcsseldorf Moorenstrasse 5 40225 D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans\u2010Dietrich","family":"R\u00f6her","sequence":"additional","affiliation":[{"name":"Department of General and Trauma Surgery University Hospital Heinrich\u2010Heine University D\u00fcsseldorf Moorenstrasse 5 40225 D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus\u2010Martin","family":"Schulte","sequence":"additional","affiliation":[{"name":"Department of General and Trauma Surgery University Hospital Heinrich\u2010Heine University D\u00fcsseldorf Moorenstrasse 5 40225 D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,10,14]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003\u20103944(02)00761\u20107"},{"key":"e_1_2_8_3_2","first-page":"351","article-title":"Delayed diagnosis of primary hyperparathyroidism","volume":"41","author":"Makhdoomi KR","year":"1996","journal-title":"J. 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