{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:45:52Z","timestamp":1791243952721,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2004,11,11]],"date-time":"2004-11-11T00:00:00Z","timestamp":1100131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intraoperative parathyroid hormone (PTH) assay (QPTH) has made possible less invasive operative approaches in the treatment of primary hyperparathyroidism with stated advantages. When compared to the traditional bilateral neck exploration (BNE), only the targeted, hypersecreting gland is excised, leaving in situ non\u2010visualized but normally functioning parathyroids. The QPTH\u2010guided limited parathyroidectomy (LPX) must be able to identify multiglandular disease (MGD), predict a successful outcome, and have a low recurrence rate. In our series, 421 patients who underwent LPX were compared to 340 undergoing BNE; all operative failures and patients followed for 6\u00a0months or longer were included. Operative failure occurred if serum calcium and PTH levels were elevated within 6\u00a0months of parathyroidectomy. Multiglandular disease was defined in the LPX group as more than one gland excision guided by QPTH or operative failure after removal of a single abnormal gland; in the BNE group it was defined as excision of more than one enlarged gland. Recurrence was defined as elevated calcium and PTH after 6\u00a0months of eucalcemia. Operative failure and MGD rates were compared using chi\u2010squared analysis. The method of Kaplan\u2010Meier and the log\u2010rank test were used to compare recurrence rates. Operative success was seen in 97% of LPX patients and in 94% of the BNE group (<jats:italic>p<\/jats:italic> = 0.02). Multiglandular disease was identified in 3% of LPX patients and 10% of BNE patients (<jats:italic>p<\/jats:italic> &lt; 0.001). There was no statistical difference in the overall recurrence rates (<jats:italic>p<\/jats:italic> = 0.23). The QPTH\u2010guided parathyroidectomy identifies MGD and allows an improved success rate with the same low recurrence rate when compared to the results of BNE.<\/jats:p>","DOI":"10.1007\/s00268-004-7708-6","type":"journal-article","created":{"date-parts":[[2004,11,5]],"date-time":"2004-11-05T17:17:42Z","timestamp":1099675062000},"page":"1287-1292","source":"Crossref","is-referenced-by-count":212,"title":["Quick Intraoperative Parathyroid Hormone Assay: Surgical Adjunct to Allow Limited Parathyroidectomy, Improve Success Rate, and Predict Outcome"],"prefix":"10.1002","volume":"28","author":[{"given":"George L.","family":"Irvin","sequence":"first","affiliation":[{"name":"DeWitt Daughtry Family Department of Surgery University of Miami\/Jackson Memorial Hospital P.O. Box 016310 (M\u2010875) 33101 Miami Florida USA"},{"name":"Sylvester Comprehensive Cancer Center 1475 NW 12 Avenue, Room 3524 33136 Miami Florida USA"},{"name":"Veterans Affairs Medical Center 1201 NW 16 Street 33125 Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen C.","family":"Solorzano","sequence":"additional","affiliation":[{"name":"DeWitt Daughtry Family Department of Surgery University of Miami\/Jackson Memorial Hospital P.O. Box 016310 (M\u2010875) 33101 Miami Florida USA"},{"name":"Sylvester Comprehensive Cancer Center 1475 NW 12 Avenue, Room 3524 33136 Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise M.","family":"Carneiro","sequence":"additional","affiliation":[{"name":"DeWitt Daughtry Family Department of Surgery University of Miami\/Jackson Memorial Hospital P.O. Box 016310 (M\u2010875) 33101 Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,11]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2003.06.001"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000124448.49794.74"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1524-153X(99)80004-9"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/33.8.1364"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.030817"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010002\u20106675\u2010z"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01665301"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197610000-00001"},{"key":"e_1_2_9_10_2","first-page":"643","article-title":"Late results of operation for primary hyperparathyroidism in 441 patients","volume":"99","author":"Rudberg C","year":"1986","journal-title":"Surgery"},{"key":"e_1_2_9_11_2","first-page":"1021","article-title":"Parathyroid hormone: before and after parathyroidectomy","volume":"100","author":"Duh QY","year":"1986","journal-title":"Surgery"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2001.118376"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2099.101833"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2003.07.009"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072\u20107515(00)00737\u20107"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/46.10.1662"},{"key":"e_1_2_9_17_2","first-page":"401","article-title":"Video\u2010assisted minimally invasive parathyroidectomy with lateral approach in patients with primary hyperparathyroidism","volume":"74","author":"Henry JF","year":"2003","journal-title":"Ann. 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