{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T00:02:25Z","timestamp":1703462545950},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,3,22]],"date-time":"2005-03-22T00:00:00Z","timestamp":1111449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deep inframanubrial parathyroid tumors have traditionally been excised through a median sternotomy. With the advent of minimally invasive surgical access, we chose to examine the treatment options and outcomes of patients with inframanubrial mediastinal parathyroid tumors. Patients with primary hyperparathyroidism seen at a university medical center over a 12\u2010year period were retrospectively reviewed. The utility of localization studies, methods of treatment, complications, and outcomes were examined in patients with a parathyroid tumor located in the mediastinum inferior to the manubrium. Patients with parathyroid adenomas located at the thoracic inlet were excluded. Sixteen patients with inframanubrial mediastinal tumors were treated during the study period. Altogether, 81% of the patients had undergone at least one prior neck exploration for primary hyperparathyroidism. Preoperative calcium and parathyroid hormone levels were 12.4 \u00b1 0.36\u00a0mg\/dl and 273 \u00b1 70 pg\/ml, respectively. Localization studies identified mediastinal parathyroid adenomas in the following locations: anterior mediastinum (<jats:italic>n<\/jats:italic> = 8), middle mediastinum (<jats:italic>n<\/jats:italic> = 7), posterior mediastinum (<jats:italic>n<\/jats:italic> = 1). Mediastinal computed tomography and technetium\u2010sestamibi scans demonstrated the best sensitivity, 92% and 85%, respectively. Seven patients underwent successful excision of the mediastinal adenoma by transcervical mediastinal exploration with the Cooper retractor. The other patients underwent angiographic ablation (<jats:italic>n<\/jats:italic> = 4), anterior mediastinotomy (<jats:italic>n<\/jats:italic> = 3), video\u2010assisted thoracoscopy (VATS) (<jats:italic>n<\/jats:italic> = 1), and VATS plus thoracotomy (<jats:italic>n<\/jats:italic> = 1). The mean hospital stay for the study group was 2.9 \u00b1 0.7\u00a0days. The complication rate was 25%. All patients were normocalcemic after a mean follow\u2010up of 15 \u00b1 7\u00a0months. Most inframanubrial mediastinal parathyroid tumors can be successfully managed without median sternotomy.<\/jats:p>","DOI":"10.1007\/s00268-004-7731-7","type":"journal-article","created":{"date-parts":[[2005,3,15]],"date-time":"2005-03-15T19:28:56Z","timestamp":1110914936000},"page":"491-494","source":"Crossref","is-referenced-by-count":14,"title":["Inframanubrial Parathyroid Glands in Patients with Primary Hyperparathyroidism: Alternatives to Sternotomy"],"prefix":"10.1002","volume":"29","author":[{"given":"Fiemu E.","family":"Nwariaku","sequence":"first","affiliation":[{"name":"Department of Surgery University of Texas Southwestern Medical Center 5323 Harry Hines Boulevard 75390\u20109156 Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Texas Southwestern Medical Center 5323 Harry Hines Boulevard 75390\u20109156 Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelby H.","family":"Burkey","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Texas Southwestern Medical Center 5323 Harry Hines Boulevard 75390\u20109156 Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori","family":"Watumull","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Texas Southwestern Medical Center 5323 Harry Hines Boulevard 75390\u20109156 Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Mathews","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Texas Southwestern Medical Center 5323 Harry Hines Boulevard 75390\u20109156 Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,3,22]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"523","article-title":"Mediastinal parathyroid adenomas: a cause of persistent hyperparathyroidism","volume":"49","author":"Roslyn JJ","year":"1983","journal-title":"Am Surg"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.173.1.10397106"},{"key":"e_1_2_6_4_2","first-page":"631","article-title":"[Mediastinal exploration by sternotomy in surgery of hyperparathyroidism; 36 cases","volume":"125","author":"Dubost CI","year":"1988","journal-title":"J Chir (Paris)"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109610(84)90481\u20101"},{"key":"e_1_2_6_6_2","first-page":"62","article-title":"The mediastinal parathyroid","volume":"57","author":"Conn JM","year":"1991","journal-title":"Am Surg."},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1988.01400330072011"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-2998(87)80041-7"},{"key":"e_1_2_6_9_2","first-page":"1535","article-title":"Technetium\u201099m\u2010sestamibi SPECT localization of mediastinal parathyroid adenoma","volume":"37","author":"Teigen EL","year":"1996","journal-title":"J. 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