{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T21:40:50Z","timestamp":1787780450483,"version":"build-2784847793"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,10]],"date-time":"2005-02-10T00:00:00Z","timestamp":1107993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL61943"],"award-info":[{"award-number":["R01 HL61943"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL60135"],"award-info":[{"award-number":["R01 HL60135"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL65916"],"award-info":[{"award-number":["R01 HL65916"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL72716"],"award-info":[{"award-number":["R01 HL72716"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EB\u2010002436"],"award-info":[{"award-number":["R01 EB\u2010002436"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["Methodist 39935"],"award-info":[{"award-number":["Methodist 39935"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08 CA85822"],"award-info":[{"award-number":["K08 CA85822"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R13 CA101889"],"award-info":[{"award-number":["R13 CA101889"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 AI 49116"],"award-info":[{"award-number":["R21 AI 49116"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DE015543"],"award-info":[{"award-number":["R01 DE015543"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cyclophilins are originally identified as cellular binding proteins for the immunosuppressive drug cyclosporin A. Many cyclophilins, including CypA, CypB, CypC, CypD, and Cyp40, have been discovered and shown to be ubiquitously distributed in many types of cells and organ systems. Recent investigations have uncovered many important properties and functions for cyclophilins including peptidyle\u2010prolyl\u2010isomerase activity and protein folding\/repair; maintaining mitochondrial functions and involvement in apoptosis; roles in regulation of T\u2010cell function and inflammation; interaction with CD147; and pathogenesis of vascular disease, human immunodeficiency virus infection, and rheumatoid arthritis. Furthermore, the expression and functions of cyclophilins may be correlated with tumor biology of several types of cancers including pancreatic carcinoma. Molecular mechanisms of cyclophilin\u2010mediated biologic events and future directions of research are discussed in this review. Understanding the roles of cyclophilins in cancers and other organ systems will be crucial in determining clinical applications for the treatment or diagnosis of human diseases.<\/jats:p>","DOI":"10.1007\/s00268-004-7812-7","type":"journal-article","created":{"date-parts":[[2005,2,11]],"date-time":"2005-02-11T03:12:54Z","timestamp":1108091574000},"page":"276-280","source":"Crossref","is-referenced-by-count":58,"title":["Roles of Cyclophilins in Cancers and Other Organ Systems"],"prefix":"10.1002","volume":"29","author":[{"given":"Qizhi","family":"Yao","sequence":"first","affiliation":[{"name":"Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery Baylor College of Medicine and The Methodist Hospital 6550 Fannin Street Houston Texas 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery Baylor College of Medicine and The Methodist Hospital 6550 Fannin Street Houston Texas 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery Baylor College of Medicine and The Methodist Hospital 6550 Fannin Street Houston Texas 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chai","sequence":"additional","affiliation":[{"name":"Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery Baylor College of Medicine and The Methodist Hospital 6550 Fannin Street Houston Texas 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Fisher","sequence":"additional","affiliation":[{"name":"Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery Baylor College of Medicine and The Methodist Hospital 6550 Fannin Street Houston Texas 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery Baylor College of Medicine and The Methodist Hospital 6550 Fannin Street Houston Texas 77030 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,10]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6238408"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1993.1664"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0079\u20106107(94)00009\u2010X"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)54484-7"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20101759(94)00249\u2010V"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)42795-0"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3070005"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.8.11.2267"},{"key":"e_1_2_9_10_2","first-page":"1101","article-title":"Determination of enzymatic catalysis for the cis\u2010trans\u2010isomerization of peptide binding in proline\u2010containing peptides","volume":"43","author":"Fischer G","year":"1984","journal-title":"Biomed. Biochim. Acta"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)35315-2"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.6.2588"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/mr.57.2.402-414.1993"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.27.120193.002253"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5293.1718"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092\u20108674(00)81588\u20103"},{"key":"e_1_2_9_17_2","first-page":"586","article-title":"Heat shock\u2010induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting","volume":"11","author":"Abravaya K","year":"1991","journal-title":"Mol. Cell Biol."},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.5.2654"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092\u20108674(00)80327\u2010X"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102613.1999.00128.x"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.4.1705"},{"key":"e_1_2_9_22_2","first-page":"53","volume-title":"The Biology of Heat Shock Proteins and Molecular Chaperones","author":"Langer T","year":"1994"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432\u20101033.1988.tb14475.x"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.8.1261"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112035200"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3630029"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3360287"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01870239"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2680153"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432\u20101033.1996.0166q.x"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.25.14559"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)32249-4"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.12.1153"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.13.7557017"},{"key":"e_1_2_9_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092\u20108674(00)80434\u20101"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb17137.x"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092\u20108674(00)81573\u20101"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092\u20108674(91)90124\u2010H"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.9.3686"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610140102"},{"key":"e_1_2_9_41_2","first-page":"63","article-title":"Quantitative comarison of rapamycin and cyclosporin effects on cytokine gene expression studied by reverse transcriptase\u2010competitive polymerase chain reaction","volume":"276","author":"Zheng XX","year":"1994","journal-title":"Transplantation"},{"key":"e_1_2_9_42_2","first-page":"365","article-title":"Calcium signalling in T cells stimulated by a cyclophilin B\u2010binding protein","volume":"297","author":"Bram RJ","year":"1994","journal-title":"Nature"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06940.x"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052284899"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.8.3511"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201593200"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.4.1758"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.9.789"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5847"},{"key":"e_1_2_9_50_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.46.29174"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200002)43:2<275::AID-ANR6>3.0.CO;2-#"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsb927"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.23.6771"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm910"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006390804515"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1379\/1466-1268(2001)006<0059:HCIAHS>2.0.CO;2"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/mc.10020"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4952"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004320000182"},{"key":"e_1_2_9_60_2","first-page":"1652","article-title":"Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non\u2010small cell lung cancer","volume":"63","author":"Campa MJ","year":"2003","journal-title":"Cancer Res."},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.9.4994"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002371-200209000-00008"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-004-7812-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-004-7812-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-004-7812-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T11:37:47Z","timestamp":1703417867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-004-7812-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,10]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["10.1007\/s00268-004-7812-7"],"URL":"https:\/\/doi.org\/10.1007\/s00268-004-7812-7","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2,10]]}}}