{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T15:52:52Z","timestamp":1774713172490,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T00:00:00Z","timestamp":1137715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["954813600"],"award-info":[{"award-number":["954813600"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park","doi-asserted-by":"publisher","award":["H020920030390"],"award-info":[{"award-number":["H020920030390"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Determining the appropriate surgery\u2010based treatment for complicated anterior mediastinal malignancies (CAMM), especially those invading the superior vena cava (SVC) and its branches, remains a challenge for general thoracic surgeons. In this report, we summarize our experience and lessons regarding this issue in order to discuss a reasonable strategy for diagnosis and treatment of CAMM. Between January 2001 and April 2003, 15 patients with CAMM invading the SVC and\/or its branches with or without invasion of other neighboring organs were surgically treated in our institution by a single surgeon team. We collected clinical data from the medical charts and from surgeons\u2019 specific notes for complicated cases, and performed a comprehensive analysis. There were 9 patients with malignant thymoma. Thymic carcinoma, teratoma, embryonal carcinoma, Hodgkin\u2019s lymphoma, non\u2010Hodgkin\u2019s lymphoma, and mixed teratoma with thymoma were diagnosed in 1 patient each. All procedures were performed via median sternotomy. Some angioplasty techniques were successfully used to resect and reconstruct the SVC. Ten of the 15 patients also underwent pulmonary resection due to involvement of pulmonary parenchyma. Four of the patients underwent perioperative chemotherapy. There were no perioperative deaths. Two patients suffered prolonged ventilation after surgery, and there were no other severe complications related to surgery. One patient died 10\u00a0months after surgery. The remaining 14 patients were still living and their progress is still monitored. As of August 2004, the median follow\u2010up duration for all patients was 35\u00a0months, and the disease\u2010free survival duration was 10\u201343\u00a0months. CAMM can be safely and completely resected via a median sternotomy, even if it has invaded other mediastinal structures. CAMM should be pathologically identified before initial treatment. A good outcome for patients with CAMM is possible if a suitable strategy combining accurate diagnosis and appropriate treatment, especially surgical resection, is established.<\/jats:p>","DOI":"10.1007\/s00268-005-0009-x","type":"journal-article","created":{"date-parts":[[2006,1,19]],"date-time":"2006-01-19T14:14:55Z","timestamp":1137680095000},"page":"162-170","source":"Crossref","is-referenced-by-count":22,"title":["Surgical Treatment of Complex Malignant Anterior Mediastinal Tumors Invading the Superior Vena Cava"],"prefix":"10.1002","volume":"30","author":[{"given":"Ke\u2010Neng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Peking University School of Oncology, Beijing Cancer Hospital 100036 Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao\u2010Fa","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Beijing Tuberculosis &amp; Thoracic Tumor Research Institute 101149 Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010Dong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Peking University School of Oncology, Beijing Cancer Hospital 100036 Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Peking University School of Oncology, Beijing Cancer Hospital 100036 Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Peking University School of Oncology, Beijing Cancer Hospital 100036 Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Zhong","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Peking University School of Oncology, Beijing Cancer Hospital 100036 Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010You","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Peking University School of Oncology, Beijing Cancer Hospital 100036 Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang\u2010Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Peking University School of Oncology, Beijing Cancer Hospital 100036 Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(91)90848-K"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002680020020"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096\u20109098(199902)70:2<95::AID\u2010JSO6>3.0.CO;2\u20108"},{"key":"e_1_2_6_5_2","first-page":"1419","volume-title":"Thoracic Surgery","author":"William EW","year":"1995"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.131.2.239"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/stcs.2000.17955"},{"key":"e_1_2_6_8_2","first-page":"427","article-title":"The primary sarcoma located in the radiologic area for the breast cancer","volume":"16","author":"Chen KN","year":"1996","journal-title":"Chin J Radiol Med Protection"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.1.25"},{"key":"e_1_2_6_10_2","first-page":"366","article-title":"The progression in the study of the normal tissues protection during the radio\u2010chemotherapy for the patients with carcinoma","volume":"20","author":"Chen KN","year":"2000","journal-title":"Chin J Radiol Med Protection"},{"key":"e_1_2_6_11_2","first-page":"307","article-title":"The cardiovascular effects of the chest irradiation","volume":"22","author":"Deng SM","year":"2002","journal-title":"Chin J Radiol Med Protection"},{"key":"e_1_2_6_12_2","first-page":"428","article-title":"The study of the irradiation\u2010induced cardiac damage in 50 patients with malignant thymoma","volume":"22","author":"Sun Y","year":"2002","journal-title":"Chin J Radiol Med Protection"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.20.1.g00ja1167"},{"key":"e_1_2_6_14_2","first-page":"79","article-title":"Cardiac damage following therapeutic chest irradiation. 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