{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:20:43Z","timestamp":1762100443793},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,21]],"date-time":"2006-01-21T00:00:00Z","timestamp":1137801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Minimally invasive radio\u2010guided parathyroidectomy (MIRP) has been embraced as an acceptable therapeutic approach to primary hyperparathyroidism. Preoperative sestamibi scanning has facilitated this technique. Here we evaluate the addition of a rapid intraoperative parathyroid hormone (iPTH) assay for patients undergoing MIRP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A series of 51 patients underwent sestamibi localization of parathyroid glands followed by MIRP for primary hyperparathyroidism. Using peripheral venous samples, iPTH levels were measured prior to gland excision, as well as post\u2010excision at 5, 10, and 15\u00a0minutes, taking a 50% reduction in iPTH level as indicative of complete excision. Next, changes in serum iPTH were compared with preoperative and postoperative changes in serum calcium, as well as levels of intraoperative ex\u2010vivo radiation counts taken by hand\u2010held gamma probe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this series, a drop of greater than 50% in iPTH levels was observed in 94% of patients (n = 48). Moreover, a significant drop in iPTH occurred within 10\u00a0minutes of excision in the majority (n = 42) of cases (<jats:italic>P<\/jats:italic> &lt; 0.004). Changes in iPTH were comparable with the therapeutic reduction in calcium levels, as well as with the change in intraoperative ex\u2010vivo gamma counts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates that the addition of an iPTH assay to MIRP provides a quick and reliable intraoperative diagnostic modality in confirming correct adenoma removal. Moreover, it precludes the requirement of frozen section.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-005-0293-5","type":"journal-article","created":{"date-parts":[[2006,1,19]],"date-time":"2006-01-19T14:14:12Z","timestamp":1137680052000},"page":"156-161","source":"Crossref","is-referenced-by-count":13,"title":["Rapid Intraoperative Parathyroid Hormone Assay\u2014More than Just a Comfort Measure"],"prefix":"10.1002","volume":"30","author":[{"given":"F.","family":"Hanif","sequence":"first","affiliation":[{"name":"Department of Surgery National University of Ireland, Cork, and Cork University Hospital Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Coffey","sequence":"additional","affiliation":[{"name":"Department of Surgery National University of Ireland, Cork, and Cork University Hospital Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"L.","family":"Romics","sequence":"additional","affiliation":[{"name":"Department of Surgery National University of Ireland, Cork, and Cork University Hospital Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"O\u2018Sullivan","sequence":"additional","affiliation":[{"name":"Department of Statistics National University of Ireland, Cork at University College Cork* Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Aftab","sequence":"additional","affiliation":[{"name":"Department of Surgery National University of Ireland, Cork, and Cork University Hospital Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. P.","family":"Redmond","sequence":"additional","affiliation":[{"name":"Department of Surgery National University of Ireland, Cork, and Cork University Hospital Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2099.101578"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100347(199810)20:7<583::AID\u2010HED1>3.0.CO;2\u2010X"},{"key":"e_1_2_6_4_2","first-page":"643","article-title":"Late results of operation for primary hyperparathyroidism in 441 patients","volume":"99","author":"Rudeberg C","year":"1986","journal-title":"Surgery"},{"key":"e_1_2_6_5_2","first-page":"991","article-title":"Persistent and recurrent sporadic primary hyperparathyroidism: histopathology, complications and results of reoperation","volume":"116","author":"Weber 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