{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:16:25Z","timestamp":1793222185755,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,4,17]],"date-time":"2006-04-17T00:00:00Z","timestamp":1145232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The management of small, nonfunctioning pancreaticoduodenal endocrine tumors (NFPET) in multiple endocrine neoplasia type 1 (MEN1) patients is still controversial. We therefore investigated the effect of surgery on survival and tumor progression in MEN1 patients with NFPET \u22642\u00a0cm by analyzing data from the Groupe des Tumeurs Endocrines (GTE) registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Among 579\u00a0MEN1 patients in the registry, 65 had NFPET \u2264 2\u00a0cm. Fifteen (23%) underwent pancreatectomy, 9 at least segmental pancreatectomies and 6 biopsies or enucleations (the surgery group), and 50 (77%) were followed conservatively (the no surgery group). Age at MEN1 and NFPET diagnosis was similar in both groups, as was size of the primary tumor. Seven (10.8%) patients had metastases. Five metastases were synchronous, and 2 (one in each group) were metachronous. Tumor size was similar in patients with or without metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no perioperative mortality. The average follow\u2010up time after NFPET diagnosis was 6.7 years in the surgery group and 3.3 years in the no surgery group. Three (4.6%) patients died during follow\u2010up, 2 due to NFPET and 1 due to thymus tumor. The 2 patients who died of NFPET had undergone pancreatic surgery at the time of NFPET diagnosis. The 2\u00a0groups did not differ significantly with respect to tumor progression [5\/15 (33%) vs 6\/38 (16%), <jats:italic>P<\/jats:italic> = 0.16]. Overall life expectancy of patients with NFPET \u22642\u00a0cm was not different than that of the 229\u00a0MEN1 patients in the registry without any pancreaticoduodenal tumor (<jats:italic>P<\/jats:italic> = 0.33).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that surgery may not be beneficial for MEN1 patients with NFPET \u22642\u00a0cm.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-005-0354-9","type":"journal-article","created":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T14:35:16Z","timestamp":1145975716000},"page":"654-662","source":"Crossref","is-referenced-by-count":160,"title":["Is Surgery Beneficial for MEN1\u00a0Patients with Small (\u22642\u00a0cm), Nonfunctioning Pancreaticoduodenal Endocrine Tumor? An Analysis of 65\u00a0Patients from the GTE"],"prefix":"10.1002","volume":"30","author":[{"given":"Frederic","family":"Triponez","sequence":"first","affiliation":[{"name":"Department of General and Endocrine Surgery University Hospital Lille France"},{"name":"Department of Thoracic and Endocrine Surgery University Hospital of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Goudet","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery University Hospital Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Dosseh","sequence":"additional","affiliation":[{"name":"Department of General and Endocrine Surgery University Hospital Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Cougard","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery University Hospital Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Bauters","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Murat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Cadiot","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology University Hospital Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Niccoli\u2010Sire","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Timone Hospital Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Calender","sequence":"additional","affiliation":[{"name":"Department of Genetics Hospital Edouard Herriot Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A. G.","family":"Proye","sequence":"additional","affiliation":[{"name":"Department of General and Endocrine Surgery University Hospital Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102796.2003.01163.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010200006000\u201000016"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423\u2010001\u20100274\u20106"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000197715.96762.68"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00367.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1993.01420180085016"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900438"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010237"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960\u20107404(03)00038\u20100"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039\u20106060(97)90203\u20108"},{"key":"e_1_2_6_12_2","unstructured":"GTE.Recommendation booklet on MEN 1. 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