{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T19:20:46Z","timestamp":1774898446299,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,4,17]],"date-time":"2006-04-17T00:00:00Z","timestamp":1145232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Neuropsychiatric symptoms and cognitive impairment are mental manifestations of primary hyperparathyroidism (pHPT). The aim of our study was to determine if surgical treatment results in a long\u2010lasting full recovery from these symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective case\u2010control study with matching pairs, mental changes were examined preoperatively and 6\u00a0months postoperatively in 30 patients with primary hyperparathyroidism and 30 patients with nontoxic nodular goiter using the Hamilton depression score and four cognitive tests: DEM Tect, MWT (multiple word test), ZVT, and Benton test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with pHPT demonstrated significantly more cognitive changes (<jats:italic>P<\/jats:italic> &lt; 0.0001) with significant improvement 6\u00a0months postoperatively (<jats:italic>P<\/jats:italic> &lt; 0.0001). Patients with pHPT presented more psychopathologic symptoms than patients of the control group (<jats:italic>P<\/jats:italic> = NS), and there was a tendency towards recovery in the pHPT group postoperatively. There was no correlation between biochemistry and psychopathologic or cognitive changes in the pHPT group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with pHPT often present with neuropsychiatric symptoms and cognitive impairment. A successful parathyroid operation improves cognitive disorders in particular.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-005-0444-8","type":"journal-article","created":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T13:59:32Z","timestamp":1145973572000},"page":"680-685","source":"Crossref","is-referenced-by-count":54,"title":["Neuropsychiatric and Cognitive Changes after Surgery for Primary Hyperparathyroidism"],"prefix":"10.1002","volume":"30","author":[{"given":"Cornelia M.E.","family":"Dotzenrath","sequence":"first","affiliation":[{"name":"Department of Surgery St. Antonius\u2010Kliniken Vogelsangstrasse 106 42109 Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Karena","family":"Kaetsch","sequence":"additional","affiliation":[{"name":"Department of Surgery St. Antonius\u2010Kliniken Vogelsangstrasse 106 42109 Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrich","family":"Pfingsten","sequence":"additional","affiliation":[{"name":"Department of Neurology St. Antonius\u2010Kliniken Vogelsangstrasse 106 42109 Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenko","family":"Cupisti","sequence":"additional","affiliation":[{"name":"Department of Surgery Heinrich\u2010Heine University Moorenstrasse 5 40225 D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Weyerbrock","sequence":"additional","affiliation":[{"name":"Department of Surgery St. Antonius\u2010Kliniken Vogelsangstrasse 106 42109 Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Vossough","sequence":"additional","affiliation":[{"name":"Department of Surgery St. Antonius\u2010Kliniken Vogelsangstrasse 106 42109 Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo E.","family":"Verde","sequence":"additional","affiliation":[{"name":"Unit of Theoretical Surgery Heinrich\u2010Heine University Moorenstrasse 5 40225 D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Ohmann","sequence":"additional","affiliation":[{"name":"Unit of Theoretical Surgery Heinrich\u2010Heine University Moorenstrasse 5 40225 D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,17]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.43.5.413"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.137.7.779"},{"key":"e_1_2_7_4_2","first-page":"72","article-title":"Self rated psychiatric symptoms in patients operated on because of primary hyperparathyroidism and in patients with long standing mild hypercalcemia","volume":"105","author":"Joburn C","year":"1989","journal-title":"Surgery"},{"key":"e_1_2_7_5_2","first-page":"677","article-title":"Neuropsychiatric manifestations in patients of primary hyperparathyroidism and outcome following surgery","volume":"12","author":"Goyal A","year":"2001","journal-title":"Ind J Med Sci"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1520\/JFS11196J"},{"key":"e_1_2_7_7_2","first-page":"149","article-title":"Incidence, type and severity of psychic symptoms in patients with sporadic primary hyperparathyroidism","volume":"15","author":"Rastad J","year":"1992","journal-title":"J Endocrinol Invest"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"e_1_2_7_9_2","first-page":"149","article-title":"The Hamilton rating scale for depression: a comprehensive review","volume":"10","author":"Hedlund JL","year":"1979","journal-title":"J Operational Psychiatry"},{"key":"e_1_2_7_10_2","volume-title":"Der Zahlenverbindungstest (ZVT)","author":"Oswald DW","year":"1987"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1037\/h0024216"},{"key":"e_1_2_7_12_2","first-page":"488","article-title":"Ein Intelligenztest f\u00fcr die \u00e4rztliche Praxis","volume":"7","author":"Lehrl S. 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