{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:15:46Z","timestamp":1760897746674},"reference-count":6,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T00:00:00Z","timestamp":1157587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients diagnosed with peritoneal carcinomatous usually survive for less than 6\u00a0months. Cytoreductive surgery allows relief of the obstruction and improvement in functional status, while intraperitoneal chemotherapy infusion provides high local concentrations of chemotherapeutic agents. Our institutional experience is reviewed to assess the selection criteria, peri\u2010operative complications, and outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We carried out a retrospective review of nine patients who had undergone aggressive cytoreductive surgery and hyperthermic intra\u2010 and early post\u2010operative chemotherapy by a single surgeon between April 2000 and October 2004. The inclusion criteria were: (1) a demonstrated absence of extra\u2010peritoneal and hepatic spread, (2) fitness of the patient and ability to tolerate cytoreductive surgery and intra\u2010operative chemotherapy, and (3) the presence of a primary tumor originating form the gastro\u2010intestinal tract (colonic, appendiceal, and gastric primaries).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven women and two men, with a median age of 55 years, were treated. The median duration of the operation was 12 hours and 55\u00a0minutes. Seven of the nine patients required the insertion of at least one chest tube. All patients were monitored in the surgical intensive care unit (SICU) for a median of 1\u00a0day, started on feeds after a median of 6\u00a0days, and were hospitalized for a median of 16\u00a0days (range:11\u201318\u00a0days). There was no peri\u2010operative mortality and only one major peri\u2010operative complication (11.1%). At the time of analysis, the median follow\u2010up was 16\u00a0months (range: 2\u201340\u00a0months), and the median disease\u2010free survival was 8\u00a0months, with four of the nine patients showing no evidence of recurrence. To date, all of the patients are still alive. A 1\u2010year survival rate of 100% is also documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This article describes our initial experience with peritonectomy and intra\u2010operative, intra\u2010peritoneal chemotherapy infusion. Our initial problems included difficulty with leakage of the chemotherapeutic agents into the thoracic cavity that had to be overcome by the early insertion of chest\u2010tubes. With appropriate patient selection, cytoreductive surgery with the infusion of intra\u2010operative chemotherapy can be considered to be a therapeutic option for some patients with diffuse peritoneal metastases, and good disease\u2010free and overall survival can be achieved with minimal morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-005-0474-2","type":"journal-article","created":{"date-parts":[[2006,9,27]],"date-time":"2006-09-27T07:38:46Z","timestamp":1159342726000},"page":"2132-2135","source":"Crossref","is-referenced-by-count":9,"title":["Lessons Learned from Initial Experience with Peritonectomy and Intra\u2010peritoneal Chemotherapy Infusion"],"prefix":"10.1002","volume":"30","author":[{"given":"M.","family":"Teo","sequence":"first","affiliation":[{"name":"Departments of Surgical and Medical Oncology National Cancer Centre of Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.F.","family":"Foo","sequence":"additional","affiliation":[{"name":"Departments of Surgical and Medical Oncology National Cancer Centre of Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.H.","family":"Koo","sequence":"additional","affiliation":[{"name":"Departments of Surgical and Medical Oncology National Cancer Centre of Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.T.","family":"Wong","sequence":"additional","affiliation":[{"name":"Departments of Surgical and Medical Oncology National Cancer Centre of Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.C.","family":"Soo","sequence":"additional","affiliation":[{"name":"Departments of Surgical and Medical Oncology National Cancer Centre of Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2000.1033"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/000313480006600607"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102168.2001.01701.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.01967.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.139.1.20"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2004.09.007"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-005-0474-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-005-0474-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-005-0474-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T12:24:54Z","timestamp":1703420694000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-005-0474-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,7]]},"references-count":6,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1007\/s00268-005-0474-2"],"URL":"https:\/\/doi.org\/10.1007\/s00268-005-0474-2","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,7]]}}}