{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:33:21Z","timestamp":1791495201635,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,5,5]],"date-time":"2006-05-05T00:00:00Z","timestamp":1146787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In recent decades liver resection has become a safe procedure, mainly because of better patient selection. Despite this progress, however, outcomes of hepatectomy in cirrhotic patients with portal hypertension are still uncertain. The aim of this study was to elucidate early and long\u2010term outcomes of liver resection in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 1985 and 2003, a total of 245 cirrhotic patients underwent hepatectomy for HCC. Altogether, 217 patients were eligible for this analysis and were divided into two groups according to the presence of portal hypertension at the time of surgery: 99 patients with portal hypertension and 118 without it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with portal hypertension had worse preoperative liver function (Child\u2010Pugh A class patients: 66.7% vs. 94.9%; <jats:italic>P<\/jats:italic> &lt; 0.0001). No differences were encountered in terms of intraoperative and pathology data. Operative mortality was similar (11.1% <jats:italic>vs.<\/jats:italic> 5.1%; <jats:italic>P<\/jats:italic> = 0.100), but patients with portal hypertension had higher morbidity (43.4% <jats:italic>vs.<\/jats:italic> 30.5%; <jats:italic>P<\/jats:italic> = 0.049) and received a higher rate of blood and plasma transfusions (51.5% <jats:italic>vs.<\/jats:italic> 32.2%, <jats:italic>P<\/jats:italic> = 0.004; 77.8% <jats:italic>vs.<\/jats:italic> 57.6%, <jats:italic>P<\/jats:italic> = 0.0017). Considering only Child\u2010Pugh A patients, short\u2010term results were similar in the two groups in terms of mortality, morbidity, and transfusion rates. The 5\u2010year survival rate was significantly higher in patients without portal hypertension (39.8% <jats:italic>vs.<\/jats:italic> 28.9%; <jats:italic>P<\/jats:italic> = 0.020), although when considering only Child\u2010Pugh A patients no difference of survival was encountered. Multivariate analysis identified Child\u2010Pugh classification, tumor diameter, and vascular invasion as independent predicting factors for survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Portal hypertension should not be considered an absolute contraindication to hepatectomy in cirrhotic patients. Child\u2010Pugh A patients with portal hypertension have short\u2010 and long\u2010term results similar to patients with normal portal pressure.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-005-0524-9","type":"journal-article","created":{"date-parts":[[2006,5,11]],"date-time":"2006-05-11T14:51:49Z","timestamp":1147359109000},"page":"992-999","source":"Crossref","is-referenced-by-count":113,"title":["Portal Hypertension: Contraindication to Liver Surgery?"],"prefix":"10.1002","volume":"30","author":[{"given":"Lorenzo","family":"Capussotti","sequence":"first","affiliation":[{"name":"Unit of Surgical Oncology Institute for Cancer Research and Treatment Strada Provinciale 142 km 3.95 10060 Candiolo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Ferrero","sequence":"additional","affiliation":[{"name":"Unit of Surgical Oncology Institute for Cancer Research and Treatment Strada Provinciale 142 km 3.95 10060 Candiolo 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