{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:14:06Z","timestamp":1773904446124,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T00:00:00Z","timestamp":1157587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Carcinoma arising in the cardioesophageal junction is a distinct clinical entity compared with tumors located in other regions of the stomach. The prognosis for adenocarcinoma of the upper stomach is considered to be relatively poorer than carcinomas of the more distal stomach. We have therefore investigated patients with carcinoma of the gastric cardia in order to evaluate the underlying cause of this poor prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Clinicopathologic features and postoperative prognosis of 101 patients with carcinoma of the cardia were evaluated and compared with findings on 1884 patients with tumors in other regions of the stomach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tumors of the cardia had a mean size of 6.8\u00a0cm, which was significantly larger than the mean size of 5.9\u00a0cm for tumors found in the middle\u2010 and lower third of the stomach. The incidence of serosal invasion, lymph node metastasis, and lymphatic and blood vessel invasion was higher in association with adenocarcinoma of the cardia than with adenocarcinoma in remaining parts of the stomach. In the analysis of patients who had undergone curative resection, the 5\u2010year survival rates were 61.6, 79.1, and 82.6% in patients with carcinoma of the cardia, upper one\u2010third, and remaining middle\u2010 and lower one\u2010third of the stomach, respectively, and the differences were statistically significant. Multivariate analysis indicated that adenocarcinoma of the gastric cardia is an independent prognostic factor. With regard to the site of recurrence, both lymph node and hematogenous recurrence were observed more frequently in the cardia than in the remaining parts of the stomach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data indicate that the prognosis of patients with adenocarcinoma of the gastric cardia is extremely poor. To improve their prognosis, new treatments in addition to gastrectomy with extensive lymph node dissection are needed.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-005-0582-z","type":"journal-article","created":{"date-parts":[[2006,9,15]],"date-time":"2006-09-15T11:06:58Z","timestamp":1158318418000},"page":"1864-1869","source":"Crossref","is-referenced-by-count":76,"title":["Distinct Recurrence Pattern and Outcome of Adenocarcinoma of the Gastric Cardia in Comparison with Carcinoma of Other Regions of the Stomach"],"prefix":"10.1002","volume":"30","author":[{"given":"Hiroaki","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Tottori University School of Medicine 36\u20101 Nishi\u2010cho 683\u20108504 Yonago Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youji","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology Tottori University 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