{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:06:13Z","timestamp":1780329973344,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,4]],"date-time":"2006-12-04T00:00:00Z","timestamp":1165190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Unilateral adrenal hyperplasia (UAH) is a rare, surgically correctable cause of primary hyperaldosteronism (PH). We report 2 cases and review the literature for cases of PH secondary to UAH successfully treated via surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two cases of UAH treated at our institution were retrospectively reviewed. In addition, we reviewed 28 cases of UAH previously reported in the English literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median patient age was 49 (range: 10\u201362) years, with a male to female ratio of 1.7:1. All patients were hypertensive, with a median preoperative systolic and diastolic blood pressure of 170 (range: 135\u2013250) mmHg and 110 (range: 75\u2013140) mmHg, respectively. Most patients were hypokalemic, with a median serum potassium level of 2.8 (range: 1.4\u20133.9) mmol\/l. Ten out of 13 patients (77%) who underwent postural studies had a decrease or no change in the plasma aldosterone level, suggesting a unilateral source of hyperaldosteronism, and 9\/17 patients (53%) who underwent a computed tomography (CT) scan were correctly localized. Twelve patients underwent adrenal scintigraphy with or without dexamethasone suppression, of whom 6 (50%) were correctly localized. In 1 patient, adrenal scintigraphy demonstrated localization to the opposite gland. Adrenal venous sampling (AVS) was performed in 22 patients and successfully localized the lesion in all the patients. At a median follow\u2010up of 12 (range: 3\u201396) months postsurgery, 47% of patients (14\/30) were completely cured of their hypertension and 50% (15\/30) had improved control. All 30 patients were cured of hypokalemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the existence of UAH remains controversial, it is increasingly accepted as a unique pathologic entity and has an excellent outcome after unilateral adrenalectomy.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-005-0594-8","type":"journal-article","created":{"date-parts":[[2006,12,16]],"date-time":"2006-12-16T04:50:40Z","timestamp":1166244640000},"page":"72-79","source":"Crossref","is-referenced-by-count":38,"title":["Primary Hyperaldosteronism Secondary to Unilateral Adrenal Hyperplasia: an Unusual Cause of Surgically Correctable Hypertension. A review of 30 cases"],"prefix":"10.1002","volume":"31","author":[{"given":"Brian K. P.","family":"Goh","sequence":"first","affiliation":[{"name":"Department of Surgery Singapore General Hospital Outram Road 169608 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeh\u2010Hong","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Urology Singapore General Hospital Outram Road 169608 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth T. E.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pathology Singapore General Hospital Outram Road 169608 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H. K.","family":"Eng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Singapore General Hospital Outram Road 169608 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney K. H.","family":"Yip","sequence":"additional","affiliation":[{"name":"Department of Urology Singapore General Hospital Outram Road 169608 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W. S.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Urology Singapore General Hospital Outram Road 169608 Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,4]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"6","article-title":"Primary aldosteronism: a new clinical syndrome","volume":"45","author":"Conn JW","year":"1955","journal-title":"J Lab Clin Med"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.3.1066"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30098-7"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109343(87)90891\u20106"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109343(65)90122\u20101"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-3-386"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-51-5-1190"},{"issue":"1","key":"e_1_2_5_9_2","first-page":"76","article-title":"A case of predominantly unilateral pseudoprimary hyperaldosteronism","volume":"49","author":"Mendlowitz M","year":"1982","journal-title":"Mt Sinai J Med"},{"issue":"10","key":"e_1_2_5_10_2","first-page":"1635","article-title":"Unilateral hypersecretion of aldosterone associated with adrenal hyperplasia as a cause of primary aldosternism","volume":"5","author":"Ganguly A","year":"1983","journal-title":"Clin Exp Hypertens A"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.6.1.75"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem\u201060\u20101\u201067"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198901000-00021"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000282488"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611\u2010199406000\u201000017"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347969"},{"issue":"2","key":"e_1_2_5_17_2","first-page":"114","article-title":"Primary aldosteronism due to unilateral adrenal hyperplasia: a case report","volume":"59","author":"Chen LG","year":"1997","journal-title":"Zhonghua Yi Xue Za Zhi (Taipei)"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347340"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.47.443"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP.6.2.153"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895\u20107061(01)02312\u20103"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.28.379"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2002.30498"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.52.435"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2004.06.051"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/3.7.576"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.193"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002\u2010022051"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.12.4526"},{"issue":"4","key":"e_1_2_5_30_2","first-page":"320","article-title":"Outcome of patients undergoing laparoscopic adenalectomy for primary hyperaldosteronism","volume":"8","author":"Goh BK","year":"2004","journal-title":"JSLS"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010004\u20107496\u2010z"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-005-0594-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-005-0594-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-005-0594-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T11:10:48Z","timestamp":1703416248000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-005-0594-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,4]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1007\/s00268-005-0594-8"],"URL":"https:\/\/doi.org\/10.1007\/s00268-005-0594-8","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,4]]}}}