{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:01:13Z","timestamp":1783630873583,"version":"3.55.0"},"reference-count":8,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,7,21]],"date-time":"2006-07-21T00:00:00Z","timestamp":1153440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NO2\u2010CO\u201091012"],"award-info":[{"award-number":["NO2\u2010CO\u201091012"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective was to analyze the frequency and factors influencing necrotic complication in female patients undergoing nipple\u2010 and areola\u2010sparing mastectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Summary and background data<\/jats:title><jats:p>Nipple\u2010 and areola\u2010sparing mastectomy has recently been shown to yield satisfactory results in a carefully selected group of breast cancer patients. The technique includes extensive undermining of the nipple\u2013areola complex, which may result in an increased rate of necrotic complications. We report our early experience with necrotic changes after nipple\u2010 and areola\u2010sparing mastectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of 38 patients undergoing nipple\u2010 and areola\u2010sparing mastectomy were analyzed retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age of the patient was 44.5 years (range 26\u201365). Necrotic complications occurred in 15.8% of patients and included: skin flap necrosis (1 case), partial nipple\u2013areola complex necrosis (2 cases), and complete nipple\u2013areola complex necrosis (3 cases). Two cases of capsular contraction were also recorded. Statistical analysis showed age below 45 years to be associated with a lower risk of necrotic complications (OR 4.51, <jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The nipple\u2010 and areola\u2010sparing mastectomy, although resulting in a relatively high frequency of necrotic complications, is a valuable surgical option for patients with small, peripheral tumors and for women undergoing prophylactic mastectomy. The procedure seems to be safer for women under 45 years of age.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-005-0650-4","type":"journal-article","created":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T13:14:17Z","timestamp":1153228457000},"page":"1410-1413","source":"Crossref","is-referenced-by-count":123,"title":["Necrotic Complications after Nipple\u2010 and Areola\u2010Sparing Mastectomy"],"prefix":"10.1002","volume":"30","author":[{"given":"Andrzej L.","family":"Komorowski","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Maria Sk\u0142odowska\u2010Curie Memorial Institute of Oncology, Cancer Centre Krakow Poland"},{"name":"Department of Surgical Oncology Maria Sk\u0142odowska\u2010Curie Memorial Institute of Oncology, Cancer Centre ul. Garncarska 11 31\u2010115 Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Zanini","sequence":"additional","affiliation":[{"name":"Department of Breast and Reconstructive Surgery Fondazione Salvatore Maugeri Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Regolo","sequence":"additional","affiliation":[{"name":"Department of Breast and Reconstructive Surgery Fondazione Salvatore Maugeri Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Carolei","sequence":"additional","affiliation":[{"name":"Department of Applied Health Sciences Pavia University Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech M.","family":"Wysocki","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Maria Sk\u0142odowska\u2010Curie Memorial Institute of Oncology, Cancer Centre Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Breast and Reconstructive Surgery Fondazione Salvatore Maugeri Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,21]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010200307000\u201000016"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0748-7983(04)00143-X"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2004.07.001"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1245\/aso.2002.9.2.165"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2001.1130"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.139.9.988"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.139.2.148"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/030089160308900311"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-005-0650-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-005-0650-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-005-0650-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T14:06:55Z","timestamp":1704290815000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-005-0650-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,21]]},"references-count":8,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1007\/s00268-005-0650-4"],"URL":"https:\/\/doi.org\/10.1007\/s00268-005-0650-4","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,21]]}}}