{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T07:57:49Z","timestamp":1768982269177,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,8,16]],"date-time":"2006-08-16T00:00:00Z","timestamp":1155686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The effect of glutamine (Gln) supplementation in patients undergoing a major operation has not been conclusively established. This study was designed to elucidate the effect of Gln supplementation on the surgical outcome after a pancreaticoduodenectomy (PD) for periampullary tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, randomized, double\u2010blind, and controlled clinical trial was undertaken for patients who underwent a classical PD or a pylorus\u2010preserving PD for periampullary tumors. The Gln and control groups received isonitrogenous amino acid, with a 0.2\u00a0g\/kg per day Gln regimen administered to the Gln group. The surgical outcome was compared in light of length of postoperative hospital stay, nutritional and chemical profiles, and complication rate between the Gln and control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty of the consecutive 143 patients who were admitted to undergo operation for periampullary tumors were enrolled in our study; 32 were in the Gln group and 28\u00a0in the control group. The two groups were comparable prior to and during the operation. The median length of the postoperative hospital stay and the postoperative nutritional and chemical profiles were not different between two groups. The overall and PD\u2010related complication rates of the Gln group (37.5% and 25.0%) and the control group (28.6% and 14.3%) were not statistically different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No significant beneficial effect of Gln supplementation with a low\u2010dose parenteral regimen was demonstrated on the surgical outcome after a PD for periampullary tumors. Therefore, we should be prudent in using Gln as a routine pharmacologic supplement to the standard nutrition in patients who undergo major operations.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-005-0678-5","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T13:43:19Z","timestamp":1156513399000},"page":"1974-1982","source":"Crossref","is-referenced-by-count":35,"title":["Missing Effect of Glutamine Supplementation on the Surgical Outcome after Pancreaticoduodenectomy for Periampullary Tumors: A Prospective, Randomized, Double\u2010blind, Controlled Clinical Trial"],"prefix":"10.1002","volume":"30","author":[{"given":"Sungho","family":"Jo","sequence":"first","affiliation":[{"name":"Department of Surgery, Samsung Medical Center Sungkyunkwan University School of Medicine 50 Irwon\u2010dong 135\u2010170 Gangnam\u2010gu Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong\u2010Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Samsung Medical Center Sungkyunkwan University School of Medicine 50 Irwon\u2010dong 135\u2010170 Gangnam\u2010gu Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Seok","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Samsung Medical Center Sungkyunkwan University School of Medicine 50 Irwon\u2010dong 135\u2010170 Gangnam\u2010gu Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun\u2010Mi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dietetics Samsung Medical Center 50 Irwon\u2010dong 135\u2010170 Gangnam\u2010gu Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung\u2010Sook","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Samsung Medical Center 50 Irwon\u2010dong 135\u2010170 Gangnam\u2010gu Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Wook","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Samsung Medical Center Sungkyunkwan University School of Medicine 50 Irwon\u2010dong 135\u2010170 Gangnam\u2010gu Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong\u2010Meen","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Samsung Medical Center Sungkyunkwan University School of Medicine 50 Irwon\u2010dong 135\u2010170 Gangnam\u2010gu Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Chul","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Surgery, Samsung Medical Center Sungkyunkwan University School of Medicine 50 Irwon\u2010dong 135\u2010170 Gangnam\u2010gu Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Il","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Samsung Medical Center Sungkyunkwan University School of Medicine 50 Irwon\u2010dong 135\u2010170 Gangnam\u2010gu Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0753\u20103322(02)00285\u20108"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00075197\u2010200303000\u201000011"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0041-87811999000100005"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246\u2010200209000\u201000011"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.2002.0569"},{"key":"e_1_2_5_7_2","first-page":"406","article-title":"[Effects of glutamine granules on protein metabolism in trauma patients]","volume":"42","author":"Peng X","year":"2004","journal-title":"Zhonghua Wai Ke Za Zhi"},{"key":"e_1_2_5_8_2","first-page":"825","article-title":"[Glutamine dipeptide enriched enteral nutrition improving gut permeability in sever burns]","volume":"79","author":"Zhou Y","year":"1999","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-10-821"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/014860719902300516"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.2001.0528"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.2000.0142"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199802000\u201000022"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199408000\u201000014"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v10.i13.1992"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(89)91254\u20103"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420100099017"},{"key":"e_1_2_5_18_2","first-page":"1039","article-title":"[Parenteral glutamine does not improve the nutritional status in patients during high\u2010dose chemotherapy and autologous peripheral stem cell transplantation]","volume":"48","author":"Benes P","year":"2002","journal-title":"Vnitr Lek"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899\u20109007(02)00847\u2010X"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/0148607193017005407"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/0148607199023003117"},{"key":"e_1_2_5_22_2","doi-asserted-by":"crossref","unstructured":"MurraySM PindoriaS. Nutrition support for bone marrow transplant patients.Cochrane Database Syst Rev(2002) :CD002920","DOI":"10.1002\/14651858.CD002920"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.9.2543S"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246\u2010200111000\u201000006"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/65.4.977"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20051463"},{"key":"e_1_2_5_27_2","volume-title":"The science and practice of nutrition support","author":"Gottschlich MM","year":"2001"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134\u2010003\u20102048\u20109"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/0148607103027004241"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(97)00017-8"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-005-0678-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-005-0678-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-005-0678-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T15:06:51Z","timestamp":1703430411000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-005-0678-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,16]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1007\/s00268-005-0678-5"],"URL":"https:\/\/doi.org\/10.1007\/s00268-005-0678-5","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,16]]}}}