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Group I (<jats:italic>n<\/jats:italic> = 240) received 1.313 g oral amoxicillin\u2013clavulanic acid 2 hours before operation, and group II (<jats:italic>n<\/jats:italic> = 240) received 1.2 g of the same drug combination intravenously approximately 30\u00a0minutes before surgery. Patients were examined four times during 1 year of follow\u2010up (at 7\u201310\u00a0days, 4\u20136 weeks, 6\u00a0months, and 12\u00a0months postoperation), and data related to surgical site infections were collected. Seventy\u2010two patients were excluded due to confounding factors during and after the operation. There were no statistically significant differences between group I (final <jats:italic>n<\/jats:italic> = 208) and group II (final <jats:italic>n<\/jats:italic> = 200) with respect to age, sex distribution, body mass index, American Anesthesiology Association grade, frequencies of different hernia types, duration of surgery, and the experience levels of the principal surgeon in the operations. One of the 208 (0.5%) patients in group I and 3 of the 200 (1.5%) patients in group II developed superficial surgical site infections (<jats:italic>p<\/jats:italic> &gt; 0.05). None of the infections required mesh removal. There were no deep surgical site infections in either group, and there was one case of hernia recurrence in each group. For patients undergoing open prosthetic repair of inguinal hernia, oral amoxicillin\u2013clavulanic acid is safe, significantly less costly, and equally effective in preventing surgical site infection as the same dose given parenterally.<\/jats:p>","DOI":"10.1007\/s00268-005-7689-0","type":"journal-article","created":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T12:04:14Z","timestamp":1117195454000},"page":"794-799","source":"Crossref","is-referenced-by-count":13,"title":["Prevention of Surgical Site Infection After Open Prosthetic Inguinal Hernia Repair: Efficacy of Parenteral Versus Oral Prophylaxis with Amoxicillin\u2010Clavulanic Acid in a Randomized Clinical Trial"],"prefix":"10.1002","volume":"29","author":[{"given":"Mehmet A.","family":"Kuzu","sequence":"first","affiliation":[{"name":"Department of Surgery Ankara University School of Medicine 06100 S\u00fdhh\u00fdye Ankara Turkery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sel\u00e7uk","family":"Hazinedaro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Surgery Ankara University School of Medicine 06100 S\u00fdhh\u00fdye Ankara Turkery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015e\u00fckr\u00fc","family":"Dolalan","sequence":"additional","affiliation":[{"name":"Department of Surgery Ankara University School of Medicine 06100 S\u00fdhh\u00fdye Ankara Turkery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam\u0131k","family":"\u00d6zkan","sequence":"additional","affiliation":[{"name":"Department of Surgery Ankara University School of Medicine 06100 S\u00fdhh\u00fdye Ankara Turkery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samet","family":"Yal\u00e7\u0131n","sequence":"additional","affiliation":[{"name":"Department of Surgery Ankara University School of Medicine 06100 S\u00fdhh\u00fdye Ankara Turkery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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