{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:14:17Z","timestamp":1763036057016},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T00:00:00Z","timestamp":1115856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sclerosing cholangitis is a rare but dreadful complication of liver hydatid surgery. Almost all scolocidal agents are associated clinically or experimentally with this complication. Cetrimide\u2013chlorhexidine combination is the most potent scolocidal agent, and this study was designed to examine its effect on the hepato\u2010pancreatico\u2010biliary system. Forty Wistar\u2010albino rats were divided into two groups. 0.5% cetrimide\u20130.05% chlorhexidine was injected into the biliary tract of study group animals and 0.9% saline ( NaCl ) into the control group through a 3\u2010mm duodenotomy. The animals were sacrificed after 90\u00a0days and histopathological examination of the liver, biliary tract, and pancreas was performed 90\u00a0days after the biliary injection. The histopathological examination showed that the lesions ranged from focal necrosis to sclerosing cholangitis to liver cirrhosis. Focal necrosis and eosinophilic inflammation were observed in all rats in the study group. The changes in the liver, biliary tract, and pancreas of the study group animals were significantly more severe than those in the control group (<jats:italic>p<\/jats:italic> &lt; 0.05). This experimental study confirms the deleterious effect of another scolocidal agents on the hepato\u2010pancreatico\u2010biliary system. Although it is a very effective scolocidal agent, it should not be used in the presence of a duct biliary\u2013cyst communication.<\/jats:p>","DOI":"10.1007\/s00268-005-7782-4","type":"journal-article","created":{"date-parts":[[2005,5,5]],"date-time":"2005-05-05T13:11:35Z","timestamp":1115298695000},"page":"754-758","source":"Crossref","is-referenced-by-count":15,"title":["The Effects of Cetrimide\u2013Chlorhexidine Combination on the Hepato\u2010Pancreatico\u2010Biliary System"],"prefix":"10.1002","volume":"29","author":[{"given":"Elvan","family":"Tozar","sequence":"first","affiliation":[{"name":"Department of General Surgery Ankara Numune Teaching and Research Hospital 06140 Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Topcu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Cumhuriyet University Faculty of Medicine 58140 Sivas Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaan","family":"Karayalcin","sequence":"additional","affiliation":[{"name":"Department of General Surgery Ankara University Faculty of Medicine 06100 Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serap Ilhan","family":"Akbay","sequence":"additional","affiliation":[{"name":"Department of pathology Ankara Numune Teaching and Research Hospital 06140 Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suleyman","family":"Hengirmen","sequence":"additional","affiliation":[{"name":"Department of General Surgery Ankara Numune Teaching and Research Hospital 06140 Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800650407"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800740403"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800570607"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1990.01410200123020"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1986.01400100070014"},{"key":"e_1_2_6_7_2","first-page":"458","article-title":"Caustic sclerosing cholangitis report of four cases and a cumulative review of the literature","volume":"41","author":"Castellano G","year":"1994","journal-title":"Hepato\u2010Gastrenterology"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109610(84)90353\u20102"},{"key":"e_1_2_6_9_2","first-page":"343","article-title":"Complications de la sterilisation per\u2010operatoire des kystes hydatiques du foie, A propos de 6 observations","volume":"117","author":"Belghiti","year":"1991","journal-title":"Chirurgie"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/1998\/78170"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102168.1998.00823.x"},{"key":"e_1_2_6_12_2","article-title":"Retrecessement du choledoque: cholecystic duodenostomie","volume":"1144","author":"Delbet P","year":"1924","journal-title":"Bull. Mem. Soc. Natl. Chir. (Paris)"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.142.6.1157"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109610(66)90339\u20104"},{"key":"e_1_2_6_15_2","first-page":"336","article-title":"Bellamy PR, Stubbs RS Instillation of scolocidal agents into hepatic hydatid cysts: can it any longer be justified?","volume":"104","author":"Prasad J.","year":"1991","journal-title":"N. Z. Med. J."},{"key":"e_1_2_6_16_2","first-page":"113","article-title":"The effect of scolocidal solutions on the biliary tracts","volume":"12","author":"Zilan A","year":"1996","journal-title":"Turk. J. Surg."},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091\u20107435(83)90201\u20103"},{"key":"e_1_2_6_18_2","first-page":"158","article-title":"The effect of scolocidal solutions on the biliary ducts","volume":"6","author":"Coskun I","year":"1992","journal-title":"Cagdas J. 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