{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:43:07Z","timestamp":1773319387535,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Simple closure followed by <jats:italic>Helicobacter pylori<\/jats:italic> (Hp) eradication has become the most used procedure in perforated ulcer treatment. However, its efficacy and safety are still to be determined. To assess recurrence and re\u2010perforation rates, and as a secondary objective, to analyze Hp infection rates in perforated ulcer patients and controls, we conducted a prospective study. Ninety\u2010two consecutive patients (ages: 19\u201396 years) were operated on between 1996 and 2002, and treated by simple closure followed by Hp eradication and NSAID avoidance. The data were prospectively collected in a database. Hp infection was diagnosed in 68 patients (73.9%). Thirty\u2010four patients (37%) consumed nonsteroidal anti\u2010inflammatory drugs (NSAIDs), and 23 (25%) had both Hp infection and NSAID antecedents. The perforation was gastric in 4 cases and pre\u2010pyloric, pyloric or duodenal in 88. There were postoperative complications in 24 patients (26%) and 4 patients died (4.3%). Hp eradication was shown in 46 patients. There was clinical ulcer recurrence in 4 (4.3%); in 3 of them recurrence manifested as re\u2010perforation, all in gastric locations. Overall relapse and re\u2010perforation 1\u2010year crude rates were 6.1% and 4.1%, respectively. Crude rates for non\u2010gastric ulcer recurrence were 0 at 1 year and 2.6% at 2 years and for non\u2010gastric ulcer re\u2010perforation rates were 0 at 1 and 2 years. This therapeutic strategy is associated with a low rate of recurrence and no re\u2010perforations in case of duodenal, pyloric, or pre\u2010pyloric perforated ulcers, but it is not acceptable for perforated gastric ulcers.<\/jats:p>","DOI":"10.1007\/s00268-005-7797-x","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T19:33:03Z","timestamp":1118431983000},"page":"849-852","source":"Crossref","is-referenced-by-count":19,"title":["Perforated Peptic Ulcer Treated by Simple Closure and Helicobacter Pylori Eradication"],"prefix":"10.1002","volume":"29","author":[{"given":"Juan C.","family":"Rodr\u00edguez\u2010Sanju\u00e1n","sequence":"first","affiliation":[{"name":"Department of General Surgery II University Hospital Marqu\u00e9s de Valdecilla, Avda. Valdecilla s\/n 39008 Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Fern\u00e1ndez\u2010Santiago","sequence":"additional","affiliation":[{"name":"Department of General Surgery II University Hospital Marqu\u00e9s de Valdecilla, Avda. Valdecilla s\/n 39008 Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa A.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of General Surgery II University Hospital Marqu\u00e9s de Valdecilla, Avda. Valdecilla s\/n 39008 Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soledad","family":"Trugeda","sequence":"additional","affiliation":[{"name":"Department of General Surgery II University Hospital Marqu\u00e9s de Valdecilla, Avda. Valdecilla s\/n 39008 Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Seco","sequence":"additional","affiliation":[{"name":"Department of General Surgery I University Hospital Marqu\u00e9s de Valdecilla, Avda Valdecilla s\/n 39008 Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando la","family":"de Torre","sequence":"additional","affiliation":[{"name":"Department of General Surgery II University Hospital Marqu\u00e9s de Valdecilla, Avda. Valdecilla s\/n 39008 Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Naranjo","sequence":"additional","affiliation":[{"name":"Department of General Surgery I University Hospital Marqu\u00e9s de Valdecilla, Avda Valdecilla s\/n 39008 Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"G\u00f3mez\u2010Fleitas","sequence":"additional","affiliation":[{"name":"Department of General Surgery II University Hospital Marqu\u00e9s de Valdecilla, Avda. Valdecilla s\/n 39008 Santander Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010200002000\u201000001"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800770126"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016\u20105107(99)70345\u20107"},{"key":"e_1_2_5_5_2","first-page":"315","article-title":"Vagotom\u00eda troncular y piloroplastia en el tratamiento de la \u00falcera duodenal no complicada: resultados a los 22\u201026 a\u00f1os de la cirugia","volume":"93","author":"Cabrol Casta\u00f1o J","year":"2001","journal-title":"Rev. Esp. Enferm. Dig."},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613015"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836\u2010199700001\u201000037"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800831237"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.10.1344"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800820325"},{"key":"e_1_2_5_11_2","first-page":"208","article-title":"Are perforated gastroduodenal ulcers related to Helicobacter pylori infection?","volume":"58","author":"Debognie JC","year":"1995","journal-title":"Acta Gastroenterol. Belg."},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(94)91460\u20105"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320302"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007\u20101323.2001.01831.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003\u20103944(01)00669\u20101"},{"key":"e_1_2_5_16_2","first-page":"99","article-title":"Prevalence of Helicobacter pylori infection in peptic ulcer perforations","volume":"131","author":"Metzger J","year":"2001","journal-title":"Swiss Med. Wkly."},{"key":"e_1_2_5_17_2","first-page":"1396","article-title":"Simple closure of chronic duodenal ulcer perforation in the era of Helicobacter pylori: an old procedure, today\u2019s solution","volume":"50","author":"Datsis AC","year":"2003","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_5_18_2","first-page":"19","article-title":"Helicobacter pylori infection delays ulcer healing in patients operated on for perforated duodenal ulcer","volume":"21","author":"Kumar D","year":"2002","journal-title":"Indian J. Gastroenterol."},{"key":"e_1_2_5_19_2","first-page":"19","article-title":"Helicobacter pylori infection in patients with perforated duodenal ulcer","volume":"19","author":"Chowdhary SK","year":"1998","journal-title":"Trop. Gastroenterol."},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072\u20107515(98)00128\u20108"},{"key":"e_1_2_5_21_2","first-page":"1610","article-title":"The effect of H. pylori in perforation of duodenal ulcer","volume":"45","author":"Mihmanli M","year":"1998","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a011668"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2565(00)70699-0"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2002.07068.x"},{"key":"e_1_2_5_25_2","first-page":"156","article-title":"The therapeutic strategies in performing emergency surgery for gastroduodenal ulcer perforation in 130 patients over 70 years of age","volume":"48","author":"Tsugawa K","year":"2001","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_5_26_2","first-page":"319","article-title":"Perforated gastric and duodenal ulcer: an analysis of prognostic factors","volume":"59","author":"Hamby LS","year":"1993","journal-title":"Am. Surg."},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1988.01400320046008"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-005-7797-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-005-7797-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-005-7797-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T09:21:14Z","timestamp":1703409674000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-005-7797-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,16]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1007\/s00268-005-7797-x"],"URL":"https:\/\/doi.org\/10.1007\/s00268-005-7797-x","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,16]]}}}