{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T13:24:25Z","timestamp":1773753865723,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2005,11,26]],"date-time":"2005-11-26T00:00:00Z","timestamp":1132963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Postoperative peritoneal adhesions are common, serious complications of general abdominal and gynecologic surgery that can lead to chronic abdominal pain, intestinal obstruction, and infertility. As yet, there are no ideal drugs that may be prescribed for patients to prevent adhesion formation effectively. In this study the effects of escin, a natural drug, on the various steps of adhesion formation were investigated. The effects of escin on increased vascular permeability induced by acetic acid in a mouse model of acute inflammation, granuloma formation in a subchronic inflammatory rat model, gastrointestinal transit in rats with intestinal paralysis, intestinal motility in postoperative patients, and postoperative adhesion formation in a rat model were observed. It was shown that escin could inhibit acute inflammation and granuloma formation, cause acceleration of gastrointestinal transit, help recover intestinal motility, and attenuate the formation of postoperative adhesions. The findings suggest that escin attenuates the formation of postoperative adhesions by inhibiting inflammation and promoting gastrointestinal transit. Thus it may be concluded that both inhibition of inflammation and increased gastrointestinal motility during the early postoperative period have a positive effect on decreasing the formation of adhesions.<\/jats:p>","DOI":"10.1007\/s00268-005-7870-5","type":"journal-article","created":{"date-parts":[[2005,11,26]],"date-time":"2005-11-26T08:38:18Z","timestamp":1132994298000},"page":"1614-1620","source":"Crossref","is-referenced-by-count":58,"title":["Escin: Inhibiting Inflammation and Promoting Gastrointestinal Transit to Attenuate Formation of Postoperative Adhesions"],"prefix":"10.1002","volume":"29","author":[{"given":"Fenghua","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Pharmacology School of Pharmacy Yantai University 264005 Yantai P.R. China"},{"name":"Shandong Engineering Research Center for Natural Drugs 264005 Shandong P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuezhi","family":"Hou","sequence":"additional","affiliation":[{"name":"Zhanhua Hospital 256800 Shandong P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanglin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shandong Engineering Research Center for Natural Drugs 264005 Shandong P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronghua","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Binzhou Medical College 256603 Shandong P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy Yantai University 264005 Yantai P.R. China"},{"name":"Shandong Engineering Research Center for Natural Drugs 264005 Shandong P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,26]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"60","article-title":"Intestinal obstruction from adhesions: how big is the problem?","volume":"72","author":"Menzies D","year":"1990","journal-title":"Ann R Coll Surg Engl"},{"key":"e_1_2_6_3_2","first-page":"147","article-title":"Prospective adhesions: their treatment and relevance in clinical practice","volume":"75","author":"Menzies D","year":"1993","journal-title":"Ann R Coll Surg Engl"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/00015458.2003.11978403"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.8.1732"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1994.1011"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.2001.0847"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024\u20103205(00)00876\u20106"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00591-3"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(99)00100-5"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(00)00551-8"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(99)00200-7"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20108741(96)01523\u20101"},{"key":"e_1_2_6_14_2","first-page":"525","article-title":"The anti\u2010inflammatory and analgesic effects of diclofenac sodium liniment","volume":"33","author":"Li ZH","year":"1996","journal-title":"Chin Pharm J"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(91)90180-T"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000076477"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015\u20100282(00)00656\u20107"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2001.6245"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015\u20100282(02)03083\u20102"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2000.6059"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800790518"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010004\u20106825\u20106"},{"key":"e_1_2_6_23_2","first-page":"141","article-title":"Prevention of postoperative adhesions","volume":"24","author":"Holtz G","year":"1980","journal-title":"J Reprod Med"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028\u20102243(94)90114\u20107"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1980.tb04503.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cveq.2003.08.014"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(89)80499-3"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1989.tb01665.x"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003840050084"},{"key":"e_1_2_6_30_2","first-page":"734","article-title":"Serum levels of interleukin 1 and tumor necrosis factor alpha correlate with peritoneal adhesion grades in humans after major abdominal surgery","volume":"64","author":"Saba AA","year":"1998","journal-title":"Am Surg"},{"key":"e_1_2_6_31_2","first-page":"569","article-title":"Effects of interleukin\u20106 and its neutralizing antibodies on peritoneal adhesion formation and wound healing","volume":"62","author":"Saba AA","year":"1996","journal-title":"Am Surg"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.2741\/chegini"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-003-7403-z"},{"key":"e_1_2_6_34_2","first-page":"231","article-title":"Oxygen free radicals and pelvic adhesion formation","volume":"36","author":"Elkins TE","year":"1991","journal-title":"II. The interaction of oxygen free radicals and adhesion\u2010preventing solutions. Int J Fertil"},{"key":"e_1_2_6_35_2","first-page":"25","article-title":"Veinotonic effect, vascular protection, antiinflammatory and free radical scavenging properties of horse chestnut extract","volume":"44","author":"Guillaume M","year":"1994","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014\u20102999(97)01616\u20106"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-005-7870-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-005-7870-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-005-7870-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T12:13:11Z","timestamp":1704715991000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-005-7870-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,26]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1007\/s00268-005-7870-5"],"URL":"https:\/\/doi.org\/10.1007\/s00268-005-7870-5","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,26]]}}}