{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:02:20Z","timestamp":1778770940250,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Knowledge of how factors related to esophageal cancer resection affect long\u2010term quality of life after surgery is scarce, and no population\u2010based studies are available. Therefore, we conducted a Swedish nationwide, prospective, population\u2010based study of how esophageal surgery\u2013related factors influence quality of life 6\u00a0months postoperatively. The Swedish Esophageal and Cardia Cancer register (SECC\u2010register) encompasses 174 hospital departments (97%). Microscopically radically operated patients responded to a validated written questionnaire assessing quality of life. The basic questionnaire (QLQ\u2010C30) and the esophagus\u2010specific module (OES\u201024) were developed by the European Organization for Research and Treatment of Cancer. The Mann\u2010Whitney test, the Jonckheere\u2010Terpstras test, and logistic regression were used in statistical analyses. Among 100\u00a0included patients, the occurrence of surgery\u2010related complications was the main predictor of reduced global quality of life 6\u00a0months after surgery (<jats:italic>p<\/jats:italic> for trend = 0.03). This effect remained after adjustment for potential confounding variables. Except for anastomotic strictures, each of the predefined complications\u2014i.e., anastomotic leakage, infections, cardiopulmonary complications, and operative technical complications\u2014contributed to decreased quality\u2010of\u2010life scores. Other potentially relevant factors\u2014e.g. degree of lymph node dissection, resection margins, operative blood loss or duration, and hospital type\u2014did not significantly affect quality of life. In conclusion, any measures that can reduce the risk of major surgery\u2013related complications can decrease the negative impact on quality of life after esophageal cancer surgery. More population\u2010based studies are warranted, however.<\/jats:p>","DOI":"10.1007\/s00268-005-7887-9","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T19:33:03Z","timestamp":1118431983000},"page":"841-848","source":"Crossref","is-referenced-by-count":69,"title":["Influence of Surgery\u2010related Factors on Quality of Life after Esophageal or Cardia Cancer Resection"],"prefix":"10.1002","volume":"29","author":[{"given":"Pernilla","family":"Viklund","sequence":"first","affiliation":[{"name":"Department of Surgical Science Karolinska University Hospital, Solna, Karolinska Institutet SE\u2010171 76 Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Lindblad","sequence":"additional","affiliation":[{"name":"Department of Surgical Science Karolinska University Hospital, Solna, Karolinska Institutet SE\u2010171 76 Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Lagergren","sequence":"additional","affiliation":[{"name":"Department of Surgical Science Karolinska University Hospital, Solna, Karolinska Institutet SE\u2010171 76 Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(20010801)92:3<549::AID\u2010CNCR1354>3.0.CO;2\u2010L"},{"key":"e_1_2_6_3_2","volume-title":"Survival of Cancer Patients in Europe: The Eurocare\u20102 Study","author":"Berrino FCR","year":"1999"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10420"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(03)01167\u20107"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003\u20104975(97)00125\u20102"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100142(20000415)88:8<1781::AID\u2010CNCR4>3.0.CO;2\u2010G"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102168.2000.01600.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.133.3.316"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4351"},{"key":"e_1_2_6_11_2","first-page":"572","article-title":"Total versus subtotal gastrectomy in cancer of the distal stomach: facts and fantasy","volume":"18","author":"Bozzetti F.","year":"1992","journal-title":"Eur. 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