{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T15:37:31Z","timestamp":1771256251261,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,3,13]],"date-time":"2006-03-13T00:00:00Z","timestamp":1142208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2006,3,13]],"date-time":"2006-03-13T00:00:00Z","timestamp":1142208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,3,13]],"date-time":"2006-03-13T00:00:00Z","timestamp":1142208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Resection line involvement has been indicated as an important prognostic factor for gastric cancer. Its late detection renders the choice of treatment difficult for surgeons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We describe the multicenter experience of a group of 11 patients with early gastric carcinoma (EGC) and positive resection confirmed at histological examination who did not undergo surgical retreatment for reasons of associated disease, surgical considerations on duodenal stump, or patient refusal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The gastric margin was involved in 4 patients, and 7 patients had duodenal resection line involvement. No surgical complications or postoperative deaths were observed. Five and 8\u2010year survival was 100% and 86%, respectively. The only patient who relapsed did not have lymph node involvement and died from liver metastases, without local recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It is sometimes difficult to accurately define the resection line in gastric cancer surgery, especially in the early stages of disease, but because of the strongly negative prognostic value of an infiltrated margin, frozen sections are recommended if neoplastic invasion is suspected and a new resection is always recommended if possible. Nevertheless, the good prognosis of resected EGC patients with resection line involvement must be considered before submitting patients with associated diseases to radical surgical retreatment.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-005-7975-x","type":"journal-article","created":{"date-parts":[[2006,3,17]],"date-time":"2006-03-17T17:13:35Z","timestamp":1142615615000},"page":"585-589","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Does Resection Line Involvement Affect Prognosis in Early Gastric Cancer Patients? An Italian Multicentric Study"],"prefix":"10.1002","volume":"30","author":[{"given":"Paolo","family":"Morgagni","sequence":"first","affiliation":[{"name":"Department of General Surgery Morgagni\u2010Pierantoni Hospital Via Forlanini 34 47100 Forl\u00ec Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Garcea","sequence":"additional","affiliation":[{"name":"Department of General Surgery Morgagni\u2010Pierantoni Hospital Via Forlanini 34 47100 Forl\u00ec Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Marrelli","sequence":"additional","affiliation":[{"name":"Surgical Oncology Unit University of Siena Siena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"de Manzoni","sequence":"additional","affiliation":[{"name":"First Division of General Surgery University of Verona 37126 Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Natalini","sequence":"additional","affiliation":[{"name":"Department of Surgery Todi\u2010Marsciano General Hospital Todi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Department of Surgery Luigi Sacco Hospital, University of Milan via GB Grassi 74 20157 Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Marchet","sequence":"additional","affiliation":[{"name":"Second Surgical Clinic University of Padua via 8 Febbraio 2 35122 Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Vittimberga","sequence":"additional","affiliation":[{"name":"Department of General Surgery Morgagni\u2010Pierantoni Hospital Via Forlanini 34 47100 Forl\u00ec 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