{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:02:09Z","timestamp":1758636129163},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T00:00:00Z","timestamp":1162857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Biliary tract infection is associated with high mortality. This study investigated the effect of glucocorticoid pretreatment on lipopolysaccharide (LPS)\u2010induced cholangitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Rats undergoing either sham operation or ligation of the extrahepatic bile duct (BDL) for 2 weeks were randomly assigned to receive intravenous injections of dexamethasone (DX) or normal saline (NS) prior to infusing LPS into the biliary tract. The plasma levels of tumor necrosis factor\u2010\u03b1 (TNF\u03b1), chemokines monocyte chemoattractant protein\u20101 (MCP\u20101) and macrophage inflammatory protein\u20102 (MIP\u20102) as well as liver mRNA expression of MCP\u20101 and MIP\u20102 were determined. Infiltration of monocytes, Kupffer cells, and neutrophils in rat liver were studied with immunohistochemistry. Oxidative liver injury was measured by the malondialdehyde (MDA) content.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dexamethasone pretreatment resulted in significantly decreased plasma levels of TNF\u03b1 at 1 hour, MCP\u20101 and MIP\u20102 at 2 and 3 hours, and decreased liver MCP\u20101\u00a0mRNA expression at 3 hours following LPS infusion in BDL\u2010DX rats than in BDL\u2010NS rats. The number of inflammatory cells in the liver was significantly different between sham\u2010 and BDL\u2010treated rats but was not affected by DX pretreatment. Pretreatment with DX resulted in significantly decreased liver MDA contents in the BDL\u2010DX group than that in the BDL\u2010NS group. Jaundiced rats pretreated with 5\u00a0mg DX prior to infusion of 1 g of LPS were 6.8 times more likely to survive than those that were not pretreated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pretreatment of jaundiced, LPS\u2010treated rats with a supraphysiological dose of dexamethasone may rescue their lives by suppression of chemokine expression and alleviation of oxidative liver injury.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-006-0143-0","type":"journal-article","created":{"date-parts":[[2006,11,10]],"date-time":"2006-11-10T13:05:27Z","timestamp":1163163927000},"page":"2217-2226","source":"Crossref","is-referenced-by-count":12,"title":["Effect of Glucocorticoid Pretreatment on Oxidative Liver Injury and Survival in Jaundiced Rats with Endotoxin Cholangitis"],"prefix":"10.1002","volume":"30","author":[{"given":"Chi Wei","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine E\u2010Da Hospital, I\u2010Shou 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