{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:25:08Z","timestamp":1774592708965,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,5]],"date-time":"2006-12-05T00:00:00Z","timestamp":1165276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The prognosis for patients with carcinoma of the ampulla of Vater is improved relative to other periampullary neoplasms. Identification of independent prognostic factors in ampullary carcinomas has been limited by the small number of tumors resected. The aim of the present study was to determine the clinicopathologic factors that influence long\u2010term survival in patients with resected ampullary carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinicopathologic data were retrospectively reviewed for patients with ampullary carcinomas radically resected between March 1987 and September 2002. The correlation between clinicopathologic variables and survival of patients after resection was examined by the Kaplan\u2010Meier method, the log\u2010rank test, and Cox proportional hazards regression. Ampullary carcinomas were radically resected in 127 patients either by pancreaticoduodenectomy (<jats:italic>n<\/jats:italic> = 124) or local resection (<jats:italic>n<\/jats:italic> = 3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hospital mortality was 9.7%. The overall actuarial survival rates (including hospital deaths) at 1, 3, 5, and 10 years were 76.2%, 46.8%, 43.3%, and 35.7%, respectively. Factors that significantly influenced survival were lymph node status (<jats:italic>P<\/jats:italic> &lt; 0.001), depth of tumor infiltration (<jats:italic>P<\/jats:italic> = 0.029), and TNM stage (<jats:italic>P<\/jats:italic> &lt; 0.001) on univariate analysis. On multivariate analysis, both depth of infiltration and lymph node status were the independent determinants of survival after resection (<jats:italic>P<\/jats:italic> = 0.003, <jats:italic>P<\/jats:italic> = 0.005, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Carcinoma of the ampulla of Vater has a higher resectability rate and a much better survival rate than pancreatic cancer. Pancreaticoduodenectomy is the treatment of choice for this tumor. Long\u2010term survival was independently influenced by the depth of tumor infiltration and lymph node metastasis.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-006-0213-3","type":"journal-article","created":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T12:20:45Z","timestamp":1166098845000},"page":"137-143","source":"Crossref","is-referenced-by-count":110,"title":["Carcinoma of the Ampulla of Vater: Factors Influencing Long\u2010term Survival of 127\u00a0Patients with Resection"],"prefix":"10.1002","volume":"31","author":[{"given":"Qi\u2010lu","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Surgery First Hospital, Peking University 100034 Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010guo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Surgery First Hospital, Peking University 100034 Beijing 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