{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:12:49Z","timestamp":1789269169207,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T00:00:00Z","timestamp":1175644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"},{"start":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T00:00:00Z","timestamp":1175644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"},{"start":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T00:00:00Z","timestamp":1175644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Solid\u2010pseudopapillary neoplasms (SPNs) of the pancreas are increasingly diagnosed, but the exact surgical management in terms of extent of the resection is not well defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients operated on in our hospital between January 1993 and March 2005 formed the study groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 659 consecutive resections for pancreatic neoplasms, 12 female patients (1.8%) with a median age of 21 years who underwent resection for (SPN) are compared with the remaining 647 pancreatic resection patients. Jaundice (SPN 0 versus PR 73%, <jats:italic>p<\/jats:italic> &lt; 0.001) and weight loss (SPN 0 versus PR 49%, <jats:italic>p<\/jats:italic> = 0.001) occurred significantly less often. Neoplasms were distributed equally among the pancreatic head (SPN 5 out of 12 patients versus PR 88%, <jats:italic>p<\/jats:italic> &lt; 0.001) and corpus\/tail (SPN 6 out of 12 patients versus PR 8%, <jats:italic>p<\/jats:italic> &lt; 0.001). The operative time was significantly shorter (SPN 233\u00a0min versus PR 280\u00a0min, <jats:italic>p<\/jats:italic> = 0.012), and there were significantly fewer complications (SPN 1 of 12 patients versus PR 48%, <jats:italic>p<\/jats:italic> = 0.007). The mortality was not different (SPN 0 versus PR 1.6%, <jats:italic>p<\/jats:italic> = 1.000), and the hospital stay was significantly shorter (SPN 9\u00a0days versus PR 15\u00a0days, <jats:italic>p<\/jats:italic> = 0.012). The median size of the neoplasms was significantly larger (SPN 6.9\u00a0cm versus PR 2.5\u00a0cm). The median number of lymph nodes harvested was significantly fewer (SPN 1 versus PR 6, <jats:italic>p<\/jats:italic> = 0.001), and lymph node metastases occurred significantly less often (SPN 0 versus PR 64%, <jats:italic>p<\/jats:italic> &lt; 0.001). The 5\u2010year survival of SPN patients was 100% and is significantly better compared with survival of patients with pancreatic adenocarcinoma (12%, <jats:italic>p<\/jats:italic> &lt; 0.001) and ampulla of Vater adenocarcinoma (22%, <jats:italic>p<\/jats:italic> = 0.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with solid\u2010pseudopapillary neoplasms of the pancreas present differently and the course of the disease is more benign. These patients can be adequately managed by pylorus\u2010preserving pancreatoduodenectomy or spleen\u2010preserving distal pancreatectomy with excellent early and long\u2010term results.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-006-0214-2","type":"journal-article","created":{"date-parts":[[2007,4,11]],"date-time":"2007-04-11T06:22:06Z","timestamp":1176272526000},"page":"1130-1135","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Management of Solid\u2010pseudopapillary Neoplasms of the Pancreas: a Comparison with Standard Pancreatic Neoplasms"],"prefix":"10.1002","volume":"31","author":[{"given":"S. M. 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M.","family":"van Gulik","sequence":"additional","affiliation":[{"name":"Department of Surgery Academic Medical Center Meibergdreef 9 1105 Amsterdam AZ The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Obertop","sequence":"additional","affiliation":[{"name":"Department of Surgery Academic Medical Center Meibergdreef 9 1105 Amsterdam AZ The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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