{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:34:04Z","timestamp":1790184844106,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,5]],"date-time":"2007-01-05T00:00:00Z","timestamp":1167955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Parathyromatosis is defined as multiple foci of benign hyperfunctioning parathyroid tissue in the neck or mediastinum. Parathyromatosis is a problematic cause of recurrent hyperparathyroidism (HPT). In renal HPT, the stimuli of the parathyroid cells persist after parathyroidectomy (PTx), and for this reason, parathyromatosis might be important in renal HPT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between July 1973 and December 2005, 1,932 patients underwent PTx for advanced renal HPT in our department. We evaluated the frequency, clinical findings and the prognosis of this kind of parathyroid disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After total PTx with forearm autograft for renal HPT, which was performed initially in our department, the risk for developing parathyromatosis was 0.11% (2\/1837); after sub\u2010total PTx, it was 5% (1\/20). The risk for developing parathyromatosis was lower after total PTx with forearm autograft than after sub\u2010total PTx (<jats:italic>P<\/jats:italic> &lt; 0.05). In patients who developed persistent or recurrent HPT and were referred to our department for neck re\u2010operation, parathyromatosis occurred in 12.1% (7\/58); in those originally operated on at our hospital, the corresponding figure was 7.1% (3\/42). This difference was not significant (<jats:italic>P<\/jats:italic> = 0.42). Only in 4 of 10 patients was parathyromatosis suggested before re\u2010operation. However, in spite of several re\u2010operations, high parathyroid hormone (PTH) levels persisted in 6 of 10 patients with parathyromatosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Parathyromatosis is a non\u2010negligible cause of recurrent renal HPT in patients who require neck re\u2010exploration. Parathyromatosis is difficult to diagnose pre\u2010operatively and completely controlled by re\u2010operation. Parathyromatosis should be kept in mind when performing neck re\u2010exploration for recurrent renal HPT.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-006-0391-z","type":"journal-article","created":{"date-parts":[[2007,1,11]],"date-time":"2007-01-11T15:49:47Z","timestamp":1168530587000},"page":"299-305","source":"Crossref","is-referenced-by-count":44,"title":["Recurrent Renal Hyperparathyroidism Caused by Parathyromatosis"],"prefix":"10.1002","volume":"31","author":[{"given":"Susumu","family":"Matsuoka","sequence":"first","affiliation":[{"name":"Department of Transplant and Endocrine Surgery Nagoya Daini Red Cross Hospital Nagoya Japan"},{"name":"Department of Transplant and Endocrine Surgery Nagoya Daini Red Cross Hospital 2\u20109 Myoken\u2010cho 466\u20108650 Nagoya Showa\u2010ku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Department of Transplant and Endocrine Surgery Nagoya Daini Red Cross Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuhiko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Transplant and Endocrine Surgery Nagoya Daini Red Cross Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Uno","sequence":"additional","affiliation":[{"name":"Department of Transplant and Endocrine Surgery Nagoya Daini Red Cross Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Transplant and Endocrine Surgery Nagoya Daini Red Cross Hospital Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Transplant and Endocrine Surgery Nagoya Daini Red Cross Hospital Nagoya 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