{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T22:01:07Z","timestamp":1772661667033,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Retroperitoneal sarcomas (RS) are a rare group of malignant soft\u2010tissue tumors; due to the flexibility of the retroperitoneum, they generally grow to a large size before becoming symptomatic, often involving surrounding structures. Therefore, the surgeon is frequently compelled to perform large excisions. The aim of this study is to assess clinical and pathological factors affecting prognosis in patients with RS who underwent surgical treatment, comparing giant forms (size \u2265 25\u00a0cm) with smaller ones (size &lt; 25\u00a0cm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The hospital records of 73 consecutive patients who underwent surgical exploration for primary RS at our unit between 1984 and 2003 were reviewed. Statistical analysis of factors influencing overall and disease\u2010free survival was performed including both the whole group of patients and only those who underwent complete surgical resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Giant RS showed a lower resectability rate than smaller forms (54.2% vs. 84.2%, <jats:italic>P<\/jats:italic> = 0.005). In the group with complete surgical excision (51 out of 73), patients with giant RS had a higher rate of adjacent organ resection compared with the smaller ones (84.2% vs. 53.1%, <jats:italic>P<\/jats:italic> = 0.023). Tumor size did not influence prognosis: after complete resection, 5\u2010year overall survival was 60.9% and 56.3% for giant RS and smaller forms respectively, while 5\u2010year disease\u2010free survival was 54.3% and 48.3% for the two groups respectively. Advanced stage, incomplete gross surgical resection, higher tumor grade, non\u2010liposarcoma histology and microscopic infiltration of margins were found to be significantly negative prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study confirms the importance of aggressive surgical management for RS, in order to offer these patients the best chance of long\u2010term survival.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-006-0433-6","type":"journal-article","created":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T16:17:20Z","timestamp":1173284240000},"page":"1047-1054","source":"Crossref","is-referenced-by-count":13,"title":["Giant Retroperitoneal Sarcomas: A Single Institution Experience"],"prefix":"10.1002","volume":"31","author":[{"given":"Giovanni B.","family":"Doglietto","sequence":"first","affiliation":[{"name":"Digestive Surgery Division, Department of Surgical Sciences, School of Medicine Catholic University Largo Gemelli 8 00168 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio P.","family":"Tortorelli","sequence":"additional","affiliation":[{"name":"Digestive Surgery Division, Department of Surgical Sciences, School of Medicine Catholic University Largo Gemelli 8 00168 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerio","family":"Papa","sequence":"additional","affiliation":[{"name":"Digestive Surgery Division, Department of Surgical Sciences, School of Medicine Catholic University Largo Gemelli 8 00168 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto","family":"Rosa","sequence":"additional","affiliation":[{"name":"Digestive Surgery Division, Department of Surgical Sciences, School of Medicine Catholic University Largo Gemelli 8 00168 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Bossola","sequence":"additional","affiliation":[{"name":"Digestive Surgery Division, Department of Surgical Sciences, School of Medicine Catholic University Largo Gemelli 8 00168 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco P.","family":"Prete","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences School of Medicine University of Foggia Via Gramsci 89\u201091 71100 Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Covino","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine School of Medicine Catholic University Largo Gemelli 8 00168 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Pacelli","sequence":"additional","affiliation":[{"name":"Digestive Surgery Division, Department of Surgical Sciences, School of Medicine Catholic University Largo Gemelli 8 00168 Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,2]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"725","article-title":"Management of retroperitoneal sarcomas","volume":"106","author":"Dalton 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