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Univariate and multivariate prognostic factor analyses were carried out using survival and regression methods in the data of 704 patients with PN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In multivariate analysis, the number of PN, ratio of PN, log odds of PN, and level III (L\u2010III) involvement, separately, were significant factors for DR in addition to age, tumor size, and lymphovascular invasion (LVI). In the final model including all expressions of nodal involvement, age (continuous<jats:italic>P<\/jats:italic>= 0.001; hazard ratio [HR]: 0.98; 95% confidence Interval [95% CI]: 0.96\u20130.99), tumor size (continuous:<jats:italic>P<\/jats:italic>&lt; 0.0001; HR: 1.3; 95% CI, 1.2\u20131.5), LVI (yes vs. no:<jats:italic>P<\/jats:italic>= 0.005; HR: 1.6; 95% CI, 1.2\u20132.2), and ratio of PN (continuous:<jats:italic>P<\/jats:italic>= 0.02; HR: 1.03; 95% CI, 1.01\u20131.06) were the independent prognostic factors for DR. For LRR, ratio of PN (continuous:<jats:italic>P<\/jats:italic>= 0.001; HR: 1.02; 95% CI, 1.01\u20131.03) was the most important factor in addition to age (continuous:<jats:italic>P<\/jats:italic>= 0.02; HR: 0.98; 95% CI, 0.97\u20130.99) and tumor size (continuous:<jats:italic>P<\/jats:italic>= 0.04; HR: 1.3; 95% CI, 1.1\u20131.6). When patients were stratified by number categories of PN (1\u20133 vs. 4\u20139 vs. \u2265 10), there was no difference between DFSs of patients with and without L\u2010III involvement. In contrast, when patients were stratified by L\u2010III involvement, DFSs according to the number categories were statistically different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ratio of PN was more valuable than number of PN for predicting outcome in node\u2010positive breast carcinoma patients. Level III involvement was not an independent prognostic indicator either for locoregional or for distant recurrences.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-006-0487-5","type":"journal-article","created":{"date-parts":[[2007,1,11]],"date-time":"2007-01-11T15:12:42Z","timestamp":1168528362000},"page":"276-289","source":"Crossref","is-referenced-by-count":47,"title":["Lymph Node Ratio is More Valuable than Level III Involvement for Prediction of Outcome in Node\u2010Positive Breast Carcinoma Patients"],"prefix":"10.1002","volume":"31","author":[{"given":"Emin","family":"Yildirim","sequence":"first","affiliation":[{"name":"Ankara Oncology Training and Research Hospital Ankara Turkey"},{"name":"Konutkent\u20102, A\u20104 Blok 44 06530 Ankara Cayyolu Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur","family":"Berberoglu","sequence":"additional","affiliation":[{"name":"Ankara Oncology Training and Research Hospital Ankara 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