{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:34:21Z","timestamp":1767706461207},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was aimed at investigating the efficacy and safety of minimally invasive laparoscopic splenectomy in patients with hypersplenism secondary to cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>While advances have been made in the treatment of liver cancer and chronic hepatitis, certain treatments such as radio frequency ablation (RFA) must often be discontinued due to thrombocytopenia caused by hypersplenism. Laparoscopic splenectomy is performed to treat diseases as idiopathic thrombocytopenic purpura, but is contraindicated for hypersplenism in many institutions. Few studies have thus examined the safety and efficacy of this approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Efficacy and safety were retrospectively analyzed for laparoscopic splenectomies starting from January 2003. Relationships between postoperative increases in platelet count and thrombopoietin, platelet\u2010associated immunoglobulin, excised spleen weight, and serum parameters were examined. Perioperative data of open splenectomies starting from January 1990 were compared with those of laparoscopic splenectomies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No laparoscopic cases were converted to open surgery in this series. Mean operative times of open and laparoscopic splenectomy were 205 and 173\u00a0min respectively. Mean blood losses were 750 and 359\u00a0ml (<jats:italic>P<\/jats:italic> &lt; 0.05) and the mean weights of excised spleen were 460 and 525 g respectively. Postoperatively, no changes in liver function were noted, and platelet and leukocyte counts were significantly increased. Compared with preoperative platelet count, degree of increase at 2 weeks postoperatively did not correlate with preoperative thrombopoietin levels, but significantly correlated with levels of platelet\u2010associated immunoglobulin and spleen volume (<jats:italic>P<\/jats:italic> &lt; 0.05). Postoperative portal or splenic vein thrombosis (PSVT) was seen in 3 patients and these patients did not exhibit any clinical symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Laparoscopic splenectomy is a safe technique for the treatment of hypersplenism and contributes to postoperative increases in platelet counts. Postoperative increases in platelet count seem to depend on platelet\u2010associated immunoglobulin level and spleen weight, which may be valuable prognosticators.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-006-0504-8","type":"journal-article","created":{"date-parts":[[2007,2,16]],"date-time":"2007-02-16T14:34:26Z","timestamp":1171636466000},"page":"549-555","source":"Crossref","is-referenced-by-count":53,"title":["Significance of Laparoscopic Splenectomy in Patients with Hypersplenism"],"prefix":"10.1002","volume":"31","author":[{"given":"Yuji","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Surgery II School of Medicine, Ehime University Shitsukawa, Toon\u2010Shi 791\u20100295 Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Department of Surgery II School of Medicine, Ehime University Shitsukawa, Toon\u2010Shi 791\u20100295 Ehime 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