{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T18:42:32Z","timestamp":1772131352739,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T00:00:00Z","timestamp":1175644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite increasingly radical surgery for esophageal carcinoma, many patients still develop tumor recurrence after operation. This study was designed to evaluate the recurrence pattern of squamous cell carcinoma in the middle thoracic esophagus after modified Ivor\u2010Lewis esophagectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed data of 196 patients who underwent modified Ivor\u2010Lewis esophagectomy with two\u2010field lymph node dissection from January 1997 to January 2001. Recurrence was classified as locoregional or hematogenous recurrence. Logistic regression analysis was performed to identify risk factors of postoperative recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall 3\u2010year and 5\u2010year survival rates in all patients were 53% and 31%, respectively. Recurrence was recognized in 96 patients (48.9%) in the 3 years after operation. The median time to tumor recurrence was 12.2\u00a0months. The pattern of recurrence was locoregional in 52 patients (mainly mediastinal in 41, single cervical\/supraclavicular in 8), hematogenous in 44 patients (simultaneous locoregional and hematogenous in 10; mainly liver, bone, or lung in 39). The locoregional recurrence rate was significantly lower in patients with postoperative radiotherapy than that in patients without postoperative radiotherapy (<jats:italic>p<\/jats:italic> = 0.02). Logistic regression analysis showed that T3 (<jats:italic>p<\/jats:italic> = 0.032), N1 (<jats:italic>p<\/jats:italic> = 0.003), and postoperative radiotherapy (<jats:italic>p<\/jats:italic> = 0.022) were independent risk factors for tumor locoregional recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>About one half of the patients would develop recurrent disease within 3 years after modified Ivor\u2010Lewis esophagectomy with two\u2010field lymph node dissection, and most of them had mediastinal lymph node, liver, bone, or lung metastasis. Postoperative radiotherapy was beneficial in the control of locoregional recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-006-0551-1","type":"journal-article","created":{"date-parts":[[2007,4,10]],"date-time":"2007-04-10T11:39:37Z","timestamp":1176205177000},"page":"1108-1115","source":"Crossref","is-referenced-by-count":77,"title":["Recurrence Pattern of Squamous Cell Carcinoma in the Middle Thoracic Esophagus after Modified Ivor\u2010Lewis Esophagectomy"],"prefix":"10.1002","volume":"31","author":[{"given":"Gang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Shandong Provincial Hospital, Shandong University 250021 Shandong Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Shandong Provincial Hospital, Shandong University 250021 Shandong Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang\u2010yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Shandong Provincial Hospital, Shandong University 250021 Shandong Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan\u2010ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Shandong Provincial Hospital, Shandong University 250021 Shandong Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,4]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102168.2000.01541.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2003.10.005"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072\u20107515(00)00349\u20105"},{"key":"e_1_2_1_5_2","volume-title":"UICC TNM Classification of Malignant Tumors","author":"Sobin LH","year":"1997"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20105223(98)70332\u20100"},{"key":"e_1_2_1_7_2","first-page":"68","article-title":"A study of correlation between early postoperative relapse with lymph node micrometastasis in patients with N0 esophageal cancer","volume":"42","author":"Wang Z","year":"2004","journal-title":"Zhong hua wai ke za zhi"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2000.102754"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199409000\u201000012"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442\u20102050.2001.00164.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199511000\u201000008"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072\u20107515(01)01177\u20102"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.08.046"},{"key":"e_1_2_1_14_2","unstructured":"AjaniJ Bekaii\u2010SaabT BostonB et al.NCCN practice guidelines for esophageal cancer (Version 1.2005). 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