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However, early postoperative oral feeding in patients with upper gastrointestinal surgery has been avoided because of concerns regarding anastomotic leakage. We investigated whether early postoperative oral feeding was advantageous for upper gastrointestinal anastomosis in comparison to parenteral feeding with a fasting period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Male Sprague\u2010Dawley rats were subjected to the same surgical manipulation, i.e., venous catheterization, gastrostomy, and proximal jejunal anastomosis. Rats were divided into two groups: the enteral nutrition (EN) group, which received nutrients via gastrostomy as a substitute for oral feeding, and the total parental nutrition (TPN) group, which was fed via a venous catheter. Identical nutritional solutions were administered to the two groups immediately after surgery. The anastomotic bursting pressure (ABP) and the content of hydroxyproline in the anastomotic tissue were measured 5\u00a0days postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ABP in the EN group was significantly higher than that in the TPN group (214.6 \u00b1 42 versus 149.5 \u00b1 49\u00a0mmHg; <jats:italic>p<\/jats:italic> &lt; 0.01). The hydroxyproline content in the EN group was also significantly higher (63.5 \u00b1 10 versus 50.5 \u00b1 12 \u03bcmol\/g dry tissue; <jats:italic>p<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early enteral feeding via gastrostomy accelerated jejunal anastomotic healing in comparison to parenteral feeding. This study clearly indicates that early oral feeding after upper gastrointestinal surgery leads to prompt anastomotic healing.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-007-9003-9","type":"journal-article","created":{"date-parts":[[2007,4,27]],"date-time":"2007-04-27T13:05:11Z","timestamp":1177679111000},"page":"1236-1241","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Early Postoperative Oral Feeding Accelerates Upper Gastrointestinal Anastomotic Healing in the Rat Model"],"prefix":"10.1002","volume":"31","author":[{"given":"Junya","family":"Fukuzawa","sequence":"first","affiliation":[{"name":"Department of Surgery, Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences University of Tsukuba, Tsukuba 1\u20101\u20101 Tennodai 305\u20108575 Tsukuba Ibaraki 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