{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:45:49Z","timestamp":1775076349254,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,4,26]],"date-time":"2007-04-26T00:00:00Z","timestamp":1177545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2007,4,26]],"date-time":"2007-04-26T00:00:00Z","timestamp":1177545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,4,26]],"date-time":"2007-04-26T00:00:00Z","timestamp":1177545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neuropsychological symptoms are found in a certain number of patients with primary hyperparathyroidism (PHPT). Preoperative and postoperative quality of life, anxiety, and depression are measured to analyze the impact of parathyroidectomy on these symptoms. In this prospective study, 66 patients underwent parathyroidectomy for PHPT and were evaluated pre\u2010 and postoperatively with two validated psychometric instruments (HADS, PHQ\u20109). Health\u2010related quality of life was measured with a 12\u2010item short\u2010form health survey (SF\u201012). Preoperatively, the median physical component score (SF\u201012) of 43.0 and mental component score of 43.5 were lower than those of the general population (52.8 and 54.2 points, respectively). One year postoperatively the mental component score increased to 48.6 (<jats:italic>p<\/jats:italic> = 0.011), whereas the physical functioning scale scored 45.3 and therefore did not change significantly (<jats:italic>p<\/jats:italic> = 0.585). Preoperatively, symptoms of depression were found in 23.4% of the patients, and 15.6% of the patients displayed symptoms of anxiety (HADS). The prevalence of depression was significantly higher in patients with preoperative serum calcium levels &gt; 11.2\u00a0mg\/dl (2.8\u00a0mmol\/L) (<jats:italic>p<\/jats:italic> = 0.015). Twelve months postoperatively, the overall proportion of patients with anxiety and depression decreased to 7.8% and 15.7%, respectively (<jats:italic>p<\/jats:italic> = NS). The severity of depression as measured with the PHQ\u20109 declined postoperatively as well. In this study, preoperative neuropsychological symptoms were related to the serum calcium levels. Postoperative health\u2010related quality of life improved significantly. Among patients with preoperative symptoms of depression and anxiety, both symptoms were alleviated significantly at the 12\u2010month follow\u2010up. Therefore, surgery for PHPT seems to be effective in reducing neuropsychological morbidity associated with PHPT.<\/jats:p>","DOI":"10.1007\/s00268-007-9006-6","type":"journal-article","created":{"date-parts":[[2007,4,25]],"date-time":"2007-04-25T16:17:28Z","timestamp":1177517848000},"page":"1204-1211","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Effect of Parathyroidectomy on Quality of Life and Neuropsychological Symptoms in Primary Hyperparathyroidism"],"prefix":"10.1002","volume":"31","author":[{"given":"Theresia","family":"Weber","sequence":"first","affiliation":[{"name":"Department of Surgery University of Heidelberg Im Neuenheimer Feld 110 69120 Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Hense","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Heidelberg Im Neuenheimer Feld 110 69120 Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Pietsch","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Rostock Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Hinz","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Heidelberg Im Neuenheimer Feld 110 69120 Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Schilling","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Nawroth","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University of Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst","family":"Klar","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Rostock Rostock Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus W.","family":"B\u00fcchler","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Heidelberg Im Neuenheimer Feld 110 69120 Heidelberg 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