{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:08:45Z","timestamp":1791198525940,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,5,22]],"date-time":"2007-05-22T00:00:00Z","timestamp":1179792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In gastric cancer, the recurrence rate is high even after curative surgery. A relevant issue is the identification of independent prognostic factors to select high\u2010risk patients; such features can be used as predictive factors for tailored therapies. In this study we have investigated the role of epidermal growth factor receptor (EGFR) expression as a prognostic marker for predicting cancer behavior and clinical outcome in gastric cancer patients undergoing potentially curative surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Epidermal growth factor receptor determination using a commercially available immunohistochemistry (IHC) kit was performed in tissues from 82 gastric cancer patients receiving primary surgical treatment and in 25\u00a0normal gastric mucosa specimens from noncancer patients. The EGFR positivity was correlated with disease recurrence and survival in univariate and multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010four percent (36 cases) of gastric cancers were EGFR positive. In 66 curatively treated patients, EGFR expression correlated with disease recurrence and poorer survival in both univariate and multivariate analyses. In a multivariate model for predicting recurrence and survival, advanced tumor extension (T<jats:sub>3<\/jats:sub> or T<jats:sub>4<\/jats:sub>), nodal metastases, and EGFR expression were the only independent covariates. In particular, EGFR expression was shown to be a significant predictor of poor prognosis among gastric cancer patients having the same stage according to the current TNM staging system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that EGFR expression may be useful in identifying high\u2010risk gastric cancer patients undergoing potentially curative surgery. Multimodal treatments should be considered in the adjuvant treatment of these patients.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-007-9016-4","type":"journal-article","created":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T11:54:22Z","timestamp":1179748462000},"page":"1458-1468","source":"Crossref","is-referenced-by-count":122,"title":["Epidermal Growth Factor Receptor (EGFR) Expression is Associated With a Worse Prognosis in Gastric Cancer Patients Undergoing Curative Surgery"],"prefix":"10.1002","volume":"31","author":[{"given":"Gennaro","family":"Galizia","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology, \u201cF. Magrassi \u2010 A. 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Lanzara\u201d Department of Clinical and Experimental Medicine and Surgery Second University of Naples School of Medicine c\/o II Policlinico, Edificio 17, Via Pansini, 5 80131 Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Imperatore","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, \u201cF. Magrassi \u2010 A. Lanzara\u201d Department of Clinical and Experimental Medicine and Surgery Second University of Naples School of Medicine c\/o II Policlinico, Edificio 17, Via Pansini, 5 80131 Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Pinto","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, \u201cF. Magrassi \u2010 A. 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