{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:56:01Z","timestamp":1770479761399,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,5,5]],"date-time":"2007-05-05T00:00:00Z","timestamp":1178323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Randomized trials suggest that laparoscopic cholecystectomy should be performed on first admission for acute cholecystitis. However, this is not widely practiced, possibly because of a perceived high conversion rate. We hypothesized that delay from onset of symptoms may increase the conversion rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective case note review of patients undergoing emergency cholecystectomy in a single institution between January 2002 and December 2005. We analyzed whether delay from onset of symptoms was related to the conversion rate in patients with a histopathological diagnosis of acute cholecystitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of patients who underwent emergency laparoscopic cholecystectomy in our institution, 32.4% (197\/608) had acute cholecystitis on histopathology. The conversion rate of those with acute cholecystitis was considerably higher (24.4%) than for those with other pathologies (6.3%). For patients with acute cholecystitis, the conversion rates increased with duration of symptoms: 9.5%, 16.1%, 38.9%, and 38.6% for delays of 0\u20132\u00a0days, 3\u20134\u00a0days, 5\u20136\u00a0days, and &gt; 6\u00a0days from symptom onset, respectively (chi\u2010square for trend = 14.27, DF = 1, <jats:italic>p<\/jats:italic> = 0.00016). Most conversions were due to the presence of acute inflammatory adhesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Early intervention for acute cholecystitis (preferably within 2\u00a0days of onset of symptoms) is most likely to result in successful laparoscopic cholecystectomy; increasing delay is associated with conversion to open surgery.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-007-9050-2","type":"journal-article","created":{"date-parts":[[2007,5,4]],"date-time":"2007-05-04T12:55:02Z","timestamp":1178283302000},"page":"1300-1303","source":"Crossref","is-referenced-by-count":52,"title":["Delay from Symptom Onset Increases the Conversion Rate in Laparoscopic Cholecystectomy for Acute Cholecystitis"],"prefix":"10.1002","volume":"31","author":[{"given":"Sirwan M.","family":"Hadad","sequence":"first","affiliation":[{"name":"Department of Surgery and Molecular Oncology Ninewells Hospital and Medical School DD1 9SY Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayant S.","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Department of Surgery and Molecular Oncology Ninewells Hospital and Medical School DD1 9SY Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Surgery and Molecular Oncology Ninewells Hospital and Medical School DD1 9SY Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoey C.","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Surgery and Molecular Oncology Ninewells Hospital and Medical School DD1 9SY Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy P.","family":"Heron","sequence":"additional","affiliation":[{"name":"Department of Surgery and Molecular Oncology Ninewells Hospital and Medical School DD1 9SY Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alastair M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Surgery and Molecular Oncology Ninewells Hospital and Medical School DD1 9SY Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4870"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199804000\u201000001"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199601000\u201000006"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109610(70)80133\u20107"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6850.394"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102168.1998.00708.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1572\u20100241.2003.04002.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00595\u2010005\u20102998\u20103"},{"key":"e_1_2_6_10_2","first-page":"20","article-title":"Consequences of prolonged wait 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