{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:02:10Z","timestamp":1771628530649,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,5,30]],"date-time":"2007-05-30T00:00:00Z","timestamp":1180483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary hyperparathyroidism (pHPT) is associated with an increased mortality attributable to cardiovascular disease (CVD), suggested to be alleviated by surgery. The exact mechanism of the beneficial influence of parathyroidectomy on survival is unknown. Furthermore, studies suggest that there is no increased mortality compared to the mortality rate in the general population during recent years. This study therefore investigated relative survival (RS), as well overall mortality associated with the clinical and biochemical variables in patients undergoing operation for sporadic pHPT. Furthermore, the influence of surgery on biochemical variables associated with pHPT was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A group of 323 patients with sporadic pHPT operated between September 1989 and July 2003 were followed from surgery over a 10\u2010year period. The median and mean follow\u2010up time was 69 and 70\u00a0months, respectively (range: 1\u2013120\u00a0months). Relative survival (RS) was calculated, and the impact of clinical and biochemical variables on overall death were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Postoperatively, serum levels of triglycerides and uric acid decreased. Glucose levels and glomerular filtration rate remained unchanged. A decreased RS was evident during the latter part of the 10 year follow\u2010up period. In the multivariate Cox\u2010analysis, diabetes mellitus (hazard ratio [HR] = 2.8, 95%; confidence interval [CI] 1.2\u20136.7), and the combination of an increased level of serum uric acid and cardiovascular disease (CVD) (HR = 8.6, 95%; CI 1.5\u201349.7) was associated with a higher mortality. The increased risk of death was evident for patients with persistently increased levels of uric acid postoperatively (HR = 4.8, 95%; CI = 1.4\u201316.01)<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients undergoing operation for pHPT had a decreased RS during a 10\u2010year follow\u2010up compared to the general population. This decrease in RS is associated with diabetes mellitus and increased levels of uric acid pre\u2010and postoperatively.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-007-9091-6","type":"journal-article","created":{"date-parts":[[2007,5,29]],"date-time":"2007-05-29T12:52:20Z","timestamp":1180443140000},"page":"1393-1400","source":"Crossref","is-referenced-by-count":17,"title":["Serum Levels of Uric Acid and Diabetes Mellitus Influence Survival after Surgery for Primary Hyperparathyroidism: A Prospective Cohort Study"],"prefix":"10.1002","volume":"31","author":[{"given":"Anders","family":"Bergenfelz","sequence":"first","affiliation":[{"name":"Department of Surgery Lund University Hospital 221 85 Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Bladstr\u00f6m","sequence":"additional","affiliation":[{"name":"Regional Tumour Registry Lund University Hospital 221 85 Lund 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