{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:34:24Z","timestamp":1792020864864,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2007,5,22]],"date-time":"2007-05-22T00:00:00Z","timestamp":1179792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In the setting of total parathyroidectomy (TPT) and parathyroid transplantation (PTx) for renal hyperparathyroidism (RHP), we evaluated long\u2010term parathyroid graft function after subcutaneous pre\u2010sternal transplantation (SCPTx). Because parathyroid glands are surrounded by fatty tissue, we postulated that results of subcutaneous implantation of parathyroid tissue after total parathyroidectomy for renal hyperparathyroidism could be at least as successful as intramuscular grafting, but without its complications<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>The study, a prospective open efficacy study of postoperative (po) diagnostic monitoring of intact parathyroid hormone (iPTH) on a cohort of surgical patients, was conducted within a university hospital with a dialysis unit. Thirty five patients (19 women and 16\u00a0men) operated on for renal hyperparathyroidism underwent TPT and SCPTx for RHP at the Department of General Surgery and the Department of Nephrology. Donostia Hospital. San Sebasti\u00e1n. Gipuzkoa. Spain, from January 2002 to December 2005. Follow\u2010up ranges from 6\u00a0months to 42\u00a0months (median: 15.4\u00a0months). The main outcome measure was evaluation of graft function by measurement of iPTH plasma level, based on serum levels of iPTH before operation and 24 h and 1, 3, 5, 15, 30, 60, 100, and 150 weeks after surgery<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Average preoperative iPTH values were 1,341.52 + 367.78 pg\/ml (mean \u00b1 SD) (range: 493\u20132,180). After TPT and PSCTx, iPTH levels became undetectable in all patients at 24 h. A level of 50 pg\/ml was established as the criterion of adequate parathyroid graft function. Values obtained at the various time intervals were as follows: 14.14 + 7.73 1 pg\/ml (mean \u00b1 SD) (range: 6\u201336) after 1 week, 53 + 77.33 pg\/ml (mean \u00b1 SD) (range: 35\u201374) after 5 weeks, 62.95 + 20.93 pg\/ml (mean \u00b1 SD) (range: 11\u201389) after 15 weeks, 77.54 + 18.84 pg\/ml (mean \u00b1 SD) (range: 24.6\u2013104.2) after 30 weeks, 109.29 + 50.22 pg\/ml (mean \u00b1 SD) (range: 54\u2013327) after 60 weeks, 134.21 + 128.64 pg\/ml (mean \u00b1 SD) (range: 43\u2013712) after 100 weeks, and 122.84 + 117.54 pg\/ml (mean \u00b1 SD) (range: 68\u2013723) after 150 weeks. Prevalence of hypoparathyroidism (intact parathyroid hormone serum level &lt; 20 pg\/ml with a normal or low serum calcium concentration) was 2\/35 (5.71%) by week 60 and recovered by week 100. Graft\u2010related recurrence was 2.85% (1\/35).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Subcutaneous pre\u2010sternal transplantation (SCPTx) after TPT and PTx for secondary (RHP) is an adequate method to replace muscular forearm parathyroid transplantation and avoid its complications. Functioning results of total parathyroidectomy and presternal subcutaneous grafting compare favorably with the published data on other surgical techniques proposed for the treatment of renal hyperparathyroidism. Results of long\u2010term follow\u2010up exceed previously reported results.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-007-9092-5","type":"journal-article","created":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T12:14:25Z","timestamp":1179749665000},"page":"1403-1409","source":"Crossref","is-referenced-by-count":18,"title":["Parathyroid Subcutaneous Pre\u2010sternal Transplantation after Parathyroidectomy for Renal Hyperparathyroidism. Long\u2010term Graft Function"],"prefix":"10.1002","volume":"31","author":[{"given":"Miguel","family":"Echenique\u2010Elizondo","sequence":"first","affiliation":[{"name":"Department of Surgery Basque Country University P. Dr. Beguiristain, 105 20014 San Sebasti\u00e1n Gipuzkoa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Amondarain","sequence":"additional","affiliation":[{"name":"Department of Surgery Donostia Hospital San Sebasti\u00e1n Gipuzkoa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Vidaur","sequence":"additional","affiliation":[{"name":"Department of Nephrology Donostia Hospital San Sebasti\u00e1n Gipuzkoa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Olalla","sequence":"additional","affiliation":[{"name":"Department of Surgery Donostia Hospital San Sebasti\u00e1n Gipuzkoa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Aribe","sequence":"additional","affiliation":[{"name":"Department of Surgery Donostia Hospital San Sebasti\u00e1n Gipuzkoa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Garrido","sequence":"additional","affiliation":[{"name":"Laboratory Donostia Hospital San Sebasti\u00e1n Gipuzkoa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Nephrology Donostia Hospital San Sebasti\u00e1n Gipuzkoa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Department of Nephrology Donostia Hospital San Sebasti\u00e1n Gipuzkoa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,22]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"34","article-title":"Transplantation of parathyroid glands in man: clinical indications and results.","volume":"78","author":"Wells 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