{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T02:21:40Z","timestamp":1793845300460,"version":"4.6.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,7,4]],"date-time":"2007-07-04T00:00:00Z","timestamp":1183507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We describe a new surgical technique of in situ intestinal ischemia\u2013reperfusion injury in the pig, which includes transection of the small bowel, extrinsic autonomic denervation, lymphatic disruption, and finally in\u2010situ cold ischemia of the graft by flushing through the first jejunal artery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Ten female pigs were used for the study. All neural and lymphatic connections to the jejunoileum were transected. The stripped superior mesenteric vessels remained as the only connections. The skeletonized mesenteric vessels were clamped and the superior mesenteric artery was cannulated through the first jejunal artery. The isolated jejunoileum was flushed with cold IGL\u20101 solution. A small incision on the superior mesenteric vein was made to allow outflow of the effluent. After the flushing process was complete, the small incision in the superior mesenteric vein was closed and the vascular clamps were removed. The proximal 70% of the graft was resected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean preoperative weight of the animals was 25.8 \u00b17.6\u00a0kg. The mean duration of the operation was 242.0 \u00b1 28.6\u00a0min. The mean cold ischemia time was 47.6 \u00b1 3.9\u00a0min. All animals survived the procedure and were sacrificed at day 8. At sacrifice, there were no adhesions. The small bowel appeared normal. On intestinal histology, there were no significant changes between specimens obtained from the animal immediately at the end of cold flushing (T0), 2 h after reperfusion (T1), and at sacrifice (T2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This novel technique for intestinal ischemia\u2013reperfusion injury in the pig provides an extremely useful model for experimental studies of immunological and cold ischemia\u2013reperfusion injury of transplanted small bowels.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-007-9127-y","type":"journal-article","created":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T02:09:26Z","timestamp":1183428566000},"page":"1863-1868","source":"Crossref","is-referenced-by-count":8,"title":["In Situ Intestinal Ischemia\u2010Reperfusion Injury in the Pig: A Model Using the First Jejunal Artery for Flushing"],"prefix":"10.1002","volume":"31","author":[{"given":"Thierry","family":"Yandza","sequence":"first","affiliation":[{"name":"Service de Chirurgie Viscerale et de Transplantation H\u00e9patique H\u00f4pital de l\u2019Archet II, Universit\u00e9 de Nice Sophia\u2010Antipolis 151 route de Saint Antoine de Ginesti\u00e8re 06002 Nice, Cedex 3 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mourad","family":"Mekaouche","sequence":"additional","affiliation":[{"name":"Station de Primatologie UPS 846 CNRS Rousset sur Arc France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Br\u00e9aud","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Infantile H\u00f4pital de L\u2019Archet II, Centre Hospitalo\u2010Universitaire de Nice 06002 Nice, Cedex 3 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Oroboscianu","sequence":"additional","affiliation":[{"name":"Service de Chirurgie 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Gugenheim","sequence":"additional","affiliation":[{"name":"Service de Chirurgie Viscerale et de Transplantation H\u00e9patique H\u00f4pital de l\u2019Archet II, Universit\u00e9 de Nice Sophia\u2010Antipolis 151 route de Saint Antoine de Ginesti\u00e8re 06002 Nice, Cedex 3 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