{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:11:08Z","timestamp":1777723868955,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T00:00:00Z","timestamp":1186617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T00:00:00Z","timestamp":1186617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T00:00:00Z","timestamp":1186617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The indications for and extent of routine lymph node dissection in patients with papillary thyroid carcinoma (PTC) are unclear. The aim of this study was to investigate the association between the extent of central lymph node dissection (CLND) and the therapeutic effects and potential risks in patients with a small PTC. A total of 103 patients with a PTC &lt;2\u00a0cm who underwent total thyroidectomy with routine CLND were divided into those who underwent routine bilateral CLND (group I) and those with ipsilateral CLND (group II). Therapeutic efficacy was evaluated by the extent of lymph node metastasis and postthyroidectomy serum thyroglobulin concentration. Patients with postoperative symptomatic hypocalcemia were considered to have postoperative hypoparathyroidism and received calcium\/vitamin D therapy. Altogether, 12 of 21 patients (57.1%) in group I and 48 of 75 (64.0%) in group II had postthyroidectomy serum thyroglobulin concentrations &lt;1.0\u00a0ng\/ml; furthermore, 17 of 21 (81.0%) in group I and 60 of 75 (80.0%) in group II had concentrations &lt;2.0\u00a0ng\/ml. Hypocalcemia symptoms were identified in 12 of 25 patients (48.0%) in group I and in 16 of 78 (20.5%) in group II (<jats:italic>p<\/jats:italic> = 0.009). The extent of the CLND did not influence the therapeutic effects in patients with small PTCs, but those who underwent bilateral CLND showed an increased rate of transient hypoparathyroidism. These findings indicate that the more conservative routine CLND is as safe as more extensive CLND for patients with a small PTC.<\/jats:p>","DOI":"10.1007\/s00268-007-9171-7","type":"journal-article","created":{"date-parts":[[2007,8,8]],"date-time":"2007-08-08T13:16:48Z","timestamp":1186579008000},"page":"1954-1959","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Extent of Routine Central Lymph Node Dissection With Small Papillary Thyroid Carcinoma"],"prefix":"10.1002","volume":"31","author":[{"given":"Yong Sang","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery Yonsei University Medical College Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Thyroid Cancer Clinic National Cancer Center, Research Institute and Hospital Kyeonggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Thyroid Cancer Clinic National Cancer Center, Research Institute and Hospital Kyeonggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"Thyroid Cancer Clinic National Cancer Center, Research Institute and Hospital Kyeonggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Sung","family":"Kang","sequence":"additional","affiliation":[{"name":"Thyroid Cancer Clinic National Cancer Center, Research Institute and Hospital Kyeonggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Sook","family":"Lee","sequence":"additional","affiliation":[{"name":"Thyroid Cancer Clinic National Cancer Center, Research Institute and Hospital Kyeonggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki\u2010Wook","family":"Chung","sequence":"additional","affiliation":[{"name":"Thyroid Cancer Clinic National Cancer Center, Research Institute and Hospital Kyeonggi\u2010do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,9]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"87","volume-title":"Surgical Endocrinology","author":"MacIver B","year":"2001"},{"key":"e_1_2_6_3_2","first-page":"315","article-title":"Papillary thyroid carcinoma: factors influencing prognosis and current therapy","volume":"14","author":"Mazzaferri EL","year":"1987","journal-title":"Semin Oncol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1990.01410180130021"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00353765"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900131"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900130"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198308000-00008"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004\u20101771"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3656-4_8"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.09.013"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(197011)26:5<1053::AID\u2010CNCR2820260513>3.0.CO;2\u2010X"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)44182-4"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1980.01380040028004"},{"key":"e_1_2_6_15_2","first-page":"1139","article-title":"Papillary thyroid microcarcinoma: a study of 535 cases observed in a 50\u2010year period","volume":"112","author":"Hay ID","year":"1992","journal-title":"Surgery"},{"key":"e_1_2_6_16_2","first-page":"107","article-title":"Preoperative diagnosis and treatment of metastases to the regional lymph nodes in papillary carcinoma of the thyroid gland","volume":"169","author":"Hamming JF","year":"1985","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01655538"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21653"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30310-4"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109610(91)90147\u20106"},{"key":"e_1_2_6_21_2","first-page":"355","volume-title":"Cervical lymph nodes. 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