{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:40:29Z","timestamp":1791178829057,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,9,26]],"date-time":"2007-09-26T00:00:00Z","timestamp":1190764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is no clear consensus on the efficacy and safety of hyaluronate\u2010carboxymethylcellulose membrane (Seprafilm) for preventing postoperative abdominal adhesion. This study is a meta\u2010analysis of the available evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A search of the MEDLINE, EMBASE, and the Cochrane Library identified eight studies that met the inclusion criteria for data extraction. Estimates of effectiveness were performed using fixed\u2010 and random\u2010effects models. The effect was calculated as an odds ratio (OR) with 95% confidence intervals (CI) using the statistical software Review Manager Version 4.2. Level of significance was set at\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Outcomes of 4203 patients were studied. The incidence of grade 0 adhesions among Seprafilm\u2010treated patients was statistically significantly more than that observed among control group patients (OR 95%CI, 3.74\u201320.34;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01). There was no significant difference in the incidence of grade 1 adhesions between Seprafilm and control groups (OR 95%CI, 0.58\u20132.71;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.56). The severity of grade 2 and grade 3 adhesions among Seprafilm\u2010treated patients was significantly less than that observed among control group patients (OR 95%CI, 0.22\u20130.93;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03; OR 95%CI, 0.09\u20130.63;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01, respectively). The incidence of intestinal obstruction after abdominal surgery was not different between Seprafilm and control groups (OR 95%CI, 0.78\u20131.23;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.84). Using Seprafilm significantly increased the incidence of abdominal abscesses (OR 95%CI, 1.06\u20132.54;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03) and anastomotic leaks (OR 95%CI, 1.18\u20133.50;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our systematic review and meta\u2010analysis showed that Seprafilm could decrease abdominal adhesions after general surgery, which may benefit patients, but could not reduce postoperative intestinal obstruction. At the same time, Seprafilm did increase abdominal abscesses and anastomotic leaks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-007-9242-9","type":"journal-article","created":{"date-parts":[[2007,9,25]],"date-time":"2007-09-25T07:45:14Z","timestamp":1190706314000},"page":"2125-2131","source":"Crossref","is-referenced-by-count":142,"title":["Efficacy and Safety of Seprafilm for Preventing Postoperative Abdominal Adhesion: Systematic Review and Meta\u2010analysis"],"prefix":"10.1002","volume":"31","author":[{"given":"Qiqiang","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of General Surgery the First Affiliated Hospital, Wenzhou Medical College 325003 Wenzhou Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengping","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of General Surgery the First Affiliated Hospital, Wenzhou Medical College 325003 Wenzhou Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"You","sequence":"additional","affiliation":[{"name":"Department of Oncological Surgery the First Affiliated Hospital, Wenzhou Medical College 325003 Wenzhou Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery the First Affiliated Hospital, Wenzhou Medical College 325003 Wenzhou Zhejiang Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,26]]},"reference":[{"issue":"1","key":"e_1_2_6_2_2","first-page":"27","article-title":"Peritoneal adhesions: incidence, cause, and prevention","volume":"24","author":"Menzies D","year":"1992","journal-title":"Surg Annu"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000050149"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.05.015"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072\u20107515(97)00127\u20100"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2004.10.023"},{"key":"e_1_2_6_7_2","unstructured":"BurgessL GreenwaltK RoweE et al. 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