{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T04:03:32Z","timestamp":1780805012106,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,9]],"date-time":"2007-11-09T00:00:00Z","timestamp":1194566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of this study was to assess the long\u2010term clinical outcomes and bowel function of patients with total colonic aganglionosis (TCA) after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The hospital records of 17 TCA patients treated surgically during 1985 to 2004 were reviewed. Long\u2010term follow\u2010up was done by telephone interviews with the parents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Primary enterostomy was performed in 13 (76%) patients. In three (17%) patients, TCA was not suspected initially. They underwent conservative surgery primarily, which required a second operation soon after. One had transverse colectomy with ileostomy. By pathologic review, nine (53%) patients had small bowel involvement of aganglionosis. Six (35%) patients died before corrective surgery. They all had extensive small bowel involvement. Among 11 patients who had a corrective operation, 10 were treated with Martin\u2019s procedure. Long\u2010term (mean 74\u00a0months) follow\u2010up was available in seven patients, and the mean weight\u2010for\u2010age percentiles was 27.1% (range 5\u201350%), the frequency of defecation was three to five times a day in four patients (57%), one or two times a day in two patients (28%), and more than five times a day in one patient (15%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TCA is difficult to diagnose; but once it is diagnosed correctly and treated by corrective surgery, outcomes seem promising. Martin\u2019s operation brought about a good outcome and enabled patients to have acceptable bowel habits. The prognosis is highly dependent on the extent of aganglionosis.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-007-9270-5","type":"journal-article","created":{"date-parts":[[2007,11,8]],"date-time":"2007-11-08T01:24:27Z","timestamp":1194485067000},"page":"62-68","source":"Crossref","is-referenced-by-count":8,"title":["Outcomes of Surgical Management of Total Colonic Aganglionosis"],"prefix":"10.1002","volume":"32","author":[{"given":"E. K.","family":"Choe","sequence":"first","affiliation":[{"name":"Department of Surgery College of Medicine, Seoul National University 28 Yongon\u2010Dong 110\u2010744 Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. B.","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Seoul National University Children\u2019s Hospital 28 Yongon\u2010Dong 110\u2010744 Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Seoul National University Children\u2019s Hospital 28 Yongon\u2010Dong 110\u2010744 Seoul Korea"},{"name":"Department of Surgery Gachon Medical Center, Gachon Medical College Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Seoul National University Children\u2019s Hospital 28 Yongon\u2010Dong 110\u2010744 Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. W.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Seoul National University Children\u2019s Hospital 28 Yongon\u2010Dong 110\u2010744 Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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