{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:52:40Z","timestamp":1783000360734,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,12,7]],"date-time":"2007-12-07T00:00:00Z","timestamp":1196985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Denervated stomach used as an esophageal substitute after esophagectomy often retains or spontaneously recovers acid production. The aims of the present study were to assess the relationship between esophageal acid exposure or gastric acidity and reflux\u2010related symptoms after esophagectomy, and to assess the ability of proton pump inhibitors (PPIs) to relieve gastroesophageal reflux\u2010related symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010four patients underwent esophageal and gastric 24\u2010h pH monitoring early after esophagectomy with gastric reconstruction. Initially, patients with both gastric acidity and reflux symptoms were treated with PPIs (Treatment group), then all patients with gastric acidity, whether symptomatic or not, were treated (Prevention group). Reflux\u2010related symptoms were correlated with esophageal acid exposure and postoperative gastric acidity. Gastric acidity was then correlated with serum anti\u2010<jats:italic>Helicobacter pylori<\/jats:italic> immunoglobulin G (IgG) titers and preoperative endoscopic findings<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen patients (36.4%) reporting reflux and showing gastric acid production were treated with PPIs, which provided relief to 13 (81.3%). Although symptoms did not correlate with the esophageal acid exposure, postoperative gastric acidity was significantly greater among patients who were symptomatic than among those who were not. Overall, acid production was lower in older patients (&gt; 64 years of age), although older patients who were <jats:italic>H. pylori<\/jats:italic>\u2010negative and without chronic atrophic gastritis also showed high levels of gastric acidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Proton pump inhibitors should be administered prophylactically early after esophagectomy to relieve and prevent reflux\u2010related symptoms. Candidates for preventive therapy include those less than 64 years of age or older patients who are <jats:italic>H. pylori<\/jats:italic>\u2010negative and without chronic atrophic gastritis.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-007-9325-7","type":"journal-article","created":{"date-parts":[[2007,12,6]],"date-time":"2007-12-06T16:34:38Z","timestamp":1196958878000},"page":"246-254","source":"Crossref","is-referenced-by-count":26,"title":["Proton Pump Inhibitors Relieve and Prevent Symptoms Related to Gastric Acidity after Esophagectomy"],"prefix":"10.1002","volume":"32","author":[{"given":"Manabu","family":"Okuyama","sequence":"first","affiliation":[{"name":"Department of Surgery Akita University School of Medicine 010\u20108543 Akita City Hondo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Motoyama","sequence":"additional","affiliation":[{"name":"Department of Surgery Akita University School of Medicine 010\u20108543 Akita City Hondo 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