{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:09:44Z","timestamp":1782212984417,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,1,30]],"date-time":"2008-01-30T00:00:00Z","timestamp":1201651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to define the role of combined major hepatectomy and pancreaticoduodenectomy in the surgical management of biliary carcinoma and to identify potential candidates for this aggressive procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted on 28 patients who underwent a combined major hepatectomy and pancreaticoduodenectomy for extrahepatic cholangiocarcinoma (<jats:italic>n<\/jats:italic> = 17) or gallbladder carcinoma (<jats:italic>n<\/jats:italic> = 11). Major hepatectomy was defined as hemihepatectomy or more extensive hepatectomy. Altogether, 11 patients underwent a Whipple procedure, and 17 had a pylorus\u2010preserving pancreaticoduodenectomy. The median follow\u2010up time was 169\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Morbidity and in\u2010hospital mortality were 82% and 21%, respectively. Overall cumulative survival rates after resection were 32% at 2 years and 11% at 5 years (median survival time 9\u00a0months). The median survival time was 6\u00a0months with a 2\u2010year survival rate of 0% in 11 patients with residual tumor, whereas the median survival time was 26\u00a0months with a 5\u2010year survival rate of 18% in 17 patients with no residual tumor (<jats:italic>P<\/jats:italic> = 0.0012). Residual tumor status was the only independent prognostic factor of significance (relative risk 4.65; <jats:italic>P<\/jats:italic> = 0.003). There were three 5\u2010year survivors (two with diffuse cholangiocarcinoma and one with gallbladder carcinoma with no bile duct involvement) among the patients with no residual tumor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combined major hepatectomy and pancreaticoduodenectomy provides survival benefit for some patients with locally advanced biliary carcinoma only if potentially curative (R0) resection is feasible. Patients with diffuse cholangiocarcinoma and gallbladder carcinoma with no bile duct involvement are potential candidates for this aggressive procedure.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-007-9393-8","type":"journal-article","created":{"date-parts":[[2008,1,29]],"date-time":"2008-01-29T18:30:31Z","timestamp":1201631431000},"page":"1067-1074","source":"Crossref","is-referenced-by-count":71,"title":["Combined Major Hepatectomy and Pancreaticoduodenectomy for Locally Advanced Biliary Carcinoma: Long\u2010Term Results"],"prefix":"10.1002","volume":"32","author":[{"given":"Toshifumi","family":"Wakai","sequence":"first","affiliation":[{"name":"Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences 1\u2010757 Asahimachi\u2010dori 951\u20108510 Chuo\u2010ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Shirai","sequence":"additional","affiliation":[{"name":"Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences 1\u2010757 Asahimachi\u2010dori 951\u20108510 Chuo\u2010ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department of Surgery Niigata Cancer Center Hospital 2\u201015\u20103 Kawagishi\u2010cho 951\u20108566 Chuo\u2010ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Surgery Niigata Cancer Center Hospital 2\u201015\u20103 Kawagishi\u2010cho 951\u20108566 Chuo\u2010ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouhei","family":"Akazawa","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics Niigata University Medical and Dental Hospital 1\u2013754 Asahimachi\u2010dori 951\u20108520 Chuo\u2010ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyoshi","family":"Hatakeyama","sequence":"additional","affiliation":[{"name":"Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences 1\u2010757 Asahimachi\u2010dori 951\u20108510 Chuo\u2010ku Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100142(19970101)79:1<26::AID\u2010CNCR5>3.0.CO;2\u2010K"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10434\u2010000\u20100055\u20104"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199611000\u201000008"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000154118.07704.ef"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2006.10.011"},{"key":"e_1_2_6_7_2","first-page":"923","article-title":"[Our experiences (5 cases) of extended right lobectomy combined with pancreato\u2010duodenectomy for the carcinoma of the gall bladder","volume":"1","author":"Takasaki K","year":"1980","journal-title":"Tan to Sui"},{"key":"e_1_2_6_8_2","first-page":"170","article-title":"Hepatopancreatoduodenectomy for advanced carcinoma of the biliary tract","volume":"38","author":"Nimura Y","year":"1991","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_9_2","first-page":"561","article-title":"Block resection of the hepatoduodenal ligament for carcinoma of the bile duct and gallbladder: surgical technique and a report of 11 cases","volume":"38","author":"Mimura H","year":"1991","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01658725"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1994.01420300069010"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800810139"},{"key":"e_1_2_6_13_2","first-page":"47","article-title":"Hepatopancreatoduodenectomy for squamous and adenosquamous carcinoma of the gallbladder","volume":"42","author":"Miyazaki K","year":"1995","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900014"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800830413"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100142(19971115)80:10<1904::AID\u2010CNCR5>3.0.CO;2\u2010N"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.02001.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00534\u2010003\u20100867\u20102"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010005\u20100380\u20107"},{"key":"e_1_2_6_20_2","first-page":"138","article-title":"Hepatopancreatoduodenectomy for superficially spreading bile duct carcinoma: a report of two 5 year survivals","volume":"43","author":"Nakamura S","year":"1996","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_21_2","first-page":"1634","article-title":"Diffuse bile duct carcinoma treated by major hepatectomy and pancreatoduodenectomy with the aid of pre\u2010operative portal vein embolization: report of two cases","volume":"46","author":"Chijiiwa K","year":"1999","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_22_2","first-page":"994","article-title":"Comparison between pancreatoduodenectomy and hepatopancreatoduodenectomy for bile duct cancer","volume":"48","author":"Yoshimi F","year":"2001","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2003.11.022"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010006\u20100005\u20109"},{"key":"e_1_2_6_25_2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/978-1-4757-3656-4","volume-title":"American Joint Committee on Cancer Staging Manual","author":"Greene FL","year":"2002"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1365-182X(17)30755-4"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199204000\u201000004"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800790721"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800840734"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010198110000\u201000008"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20906"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.06.014"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10578"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1091\u2010255X(02)00039\u20102"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010005\u20100181\u2010z"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2006.10.024"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.03.091"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00534\u2010006\u20101108\u20102"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199803000\u201000013"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102168.2002.02211.x"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i41.6554"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010002\u20106702\u20100"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005340100017"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2004.03.011"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00534\u2010006\u20101107\u20103"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005340100018"},{"key":"e_1_2_6_47_2","first-page":"80","article-title":"A new technique for assessing the resectability of hilar cholangiocarcinoma: lifting of the umbilical portion of the portal vein","volume":"184","author":"Shirai Y","year":"1997","journal-title":"J Am Coll Surg"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-007-9393-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-007-9393-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-007-9393-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T23:10:03Z","timestamp":1703632203000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-007-9393-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,30]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1007\/s00268-007-9393-8"],"URL":"https:\/\/doi.org\/10.1007\/s00268-007-9393-8","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,30]]}}}