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BMD was examined in 28 patients before laparoscopic adrenalectomy; 17 patients with reduced BMD were then included in the longitudinal evaluation. BMD was determined using dual energy X\u2010ray absorptiometry (DXA) before and at 3, 6, 12, 18, and 24\u00a0months after adrenalectomy. The prevalence of osteoporosis was 64% (95% confidence interval 44\u201381%). Preoperative BMD of the lumbar spine in the lateral projection was significantly lower than that of the femoral neck (mean \u00b1 SD score: \u22123.53 \u00b1 0.75 vs. \u22121.54 \u00b1 0.22, <jats:italic>p<\/jats:italic> = 0.003). A significant increase in BMD was observed at 3\u00a0months after surgery in the lumbar spine (<jats:italic>p<\/jats:italic> = 0.0004). Improvement at both sites was maintained at 24\u00a0months after surgery. The postoperative percentage change in BMD of the lumbar spine was significantly higher than that of the femoral neck (mean \u00b1 SD 36.7% \u00b1 26.5% vs. 11.2% \u00b1 12.1%, <jats:italic>p<\/jats:italic> = 0.01). The change in the seven premenopausal patients was significantly higher than that in the three postmenopausal patients (<jats:italic>p<\/jats:italic> = 0.0006). Surgical cure of hypercortisolism provides significant improvement in BMD in patients with Cushing\u2019s syndrome due to adrenal adenoma. The improvement is particularly apparent in the lumbar spine measured in the lateral projection. Premenopausal women are more likely to benefit from surgery in terms of secondary osteoporosis.<\/jats:p>","DOI":"10.1007\/s00268-007-9394-7","type":"journal-article","created":{"date-parts":[[2008,1,22]],"date-time":"2008-01-22T00:15:06Z","timestamp":1200960906000},"page":"890-896","source":"Crossref","is-referenced-by-count":51,"title":["Bone Mineral Density Before and After Surgical Cure of Cushing\u2019s Syndrome Due to Adrenocortical Adenoma: Prospective Study"],"prefix":"10.1002","volume":"32","author":[{"given":"Akiko","family":"Kawamata","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery Tokyo Women\u2019s Medical University 8\u20101 Kawada\u2010cho 162\u20108666 Shinjuku\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Iihara","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Tokyo Women\u2019s Medical University 8\u20101 Kawada\u2010cho 162\u20108666 Shinjuku\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Tokyo Women\u2019s Medical University 8\u20101 Kawada\u2010cho 162\u20108666 Shinjuku\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Obara","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Tokyo Women\u2019s Medical University 8\u20101 Kawada\u2010cho 162\u20108666 Shinjuku\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,23]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"137","article-title":"The basophil adenomas of the pituitary body and their clinical manifestation (pituitary basophilism)","volume":"50","author":"Cushing H","year":"1932","journal-title":"Bull Johns Hopkins 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