{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:22:50Z","timestamp":1783441370792,"version":"3.54.6"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,1,31]],"date-time":"2008-01-31T00:00:00Z","timestamp":1201737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Primary hyperparathyroidism (1\u00b0 HPT) is reported most often in women over the age of 50. Beyond that, little is known about the epidemiology of this condition, and no studies have specifically examined the age and gender distribution of patients with 1\u00b0 HPT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed patients from the Nationwide Inpatient Sample (NIS), a 20% random sample of all hospital stays from 2000\u20132004, and also from the University of Michigan endocrine surgery database from 1999\u20132005. Surgically treated 1\u00b0 HPT was used as a surrogate marker for 1\u00b0 HPT. An age\u2010 and sex\u2010based frequency distribution was computed for each dataset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 7,513 females and 2,677\u00a0males who underwent surgery for 1\u00b0 HPT in the 5\u2010year period 2000 through 2004 were reported in the NIS. At the University of Michigan from 1999 through 2005, 790 females and 276\u00a0males underwent parathyroidectomy for 1\u00b0 HPT. In both datasets, the frequency of 1\u00b0 HPT began to rise slowly in both sexes at age 11 and increased more rapidly among females than males beginning at age 21\u201325 (NIS) and 26\u201330 (UM). Incidence curves for both women and men in both databases were similar in shape and unipolar in configuration. Peak incidence was at age 56\u201360 (NIS) and 61\u201365 (UM) in females and age 56\u201360\u00a0in males (both datasets). The female:male ratio was noted to rise steadily among the NIS patients until perimenopausal age, after which it became stable for the next 20 years before decreasing again. No change in the female:male ratio over time was seen among the UM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Primary HPT occurs more frequently in females than in males at all ages. The incidence increases steadily after age 25\u00a0in both sexes. The female:male ratio does not change during the peri\u2010 and postmenopausal years. This information should stimulate new hypotheses to explain the difference in the incidence of 1\u00b0HPT between men and women.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-007-9427-2","type":"journal-article","created":{"date-parts":[[2008,1,30]],"date-time":"2008-01-30T12:57:09Z","timestamp":1201697829000},"page":"795-799","source":"Crossref","is-referenced-by-count":59,"title":["Age\u2010 and Sex\u2010Related Incidence of Surgically Treated Primary Hyperparathyroidism"],"prefix":"10.1002","volume":"32","author":[{"given":"Barbra S.","family":"Miller","sequence":"first","affiliation":[{"name":"Division of Endocrine Surgery, Department of Surgery University of Michigan, TC2920F University Hospital 1500 E. Medical Center Dr 48109\u20105331 Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Dimick","sequence":"additional","affiliation":[{"name":"Division of Endocrine Surgery, Department of Surgery University of Michigan, TC2920F University Hospital 1500 E. Medical Center Dr 48109\u20105331 Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reid","family":"Wainess","sequence":"additional","affiliation":[{"name":"Division of Endocrine Surgery, Department of Surgery University of Michigan, TC2920F University Hospital 1500 E. Medical Center Dr 48109\u20105331 Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Burney","sequence":"additional","affiliation":[{"name":"Division of Endocrine Surgery, Department of Surgery University of Michigan, TC2920F University Hospital 1500 E. Medical Center Dr 48109\u20105331 Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,31]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198001243020402"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650061409"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-6-199703150-00003"},{"issue":"2","key":"e_1_2_6_5_2","first-page":"N12","article-title":"The epidemiology of primary hyperparathyroidism in North America","volume":"17","author":"Melton LJ","year":"2002","journal-title":"J Bone Miner Res"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050910"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026508829397"},{"key":"e_1_2_6_8_2","first-page":"N18","article-title":"Epidemiology of hyperparathyroidism in Europe","volume":"17","author":"Adami S","year":"2002","journal-title":"J Bone Miner Res"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01665300"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102265.1991.tb00302.x"},{"key":"e_1_2_6_11_2","volume-title":"Healthcare Cost and Utilization Project (HCUP)","author":"HCUP Nationwide Inpatient Sample (NIS)","year":"2000"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2001\u20105002"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.128558"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109610(98)00302\u2010X"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102796.2001.00849.x"},{"key":"e_1_2_6_16_2","volume-title":"Healthcare Cost and Utilization Project (HCUP)","author":"HCUP State Ambulatory Surgery Databases (SASD)","year":"2000"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-007-9427-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-007-9427-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-007-9427-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T15:03:02Z","timestamp":1704898982000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-007-9427-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,31]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1007\/s00268-007-9427-2"],"URL":"https:\/\/doi.org\/10.1007\/s00268-007-9427-2","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,31]]}}}