{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:48:58Z","timestamp":1773773338971,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,2,8]],"date-time":"2008-02-08T00:00:00Z","timestamp":1202428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anastomosis leakage is a major complication of rectal surgery. The aim of this study was to identify risk factors for anastomotic leakage after low anterior resection (LAR) in rectal cancer patients and study its impact on long\u2010term prognosis and disease\u2010free survival and overall survival in rectal cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients who underwent rectal resection with primary anastomosis below the pelvic peritoneal reflexion for rectal cancer between October 1996 to February 2006 were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anastomosis leakage after LAR occurred in 51 patients (4.0%). The median time to leakage was 4\u00a0days (range = 2\u201330\u00a0days). In univariate analysis, gender, level of anastomosis less than 4\u00a0cm, preoperative concomitant chemoradiation (CCRT), and length of operation greater than 120\u00a0min were significantly associated with anastomosis leakage. In a multivariate analysis, gender (<jats:italic>p<\/jats:italic> = 0.041; relative risk = 2.007; 95% CI = 1.030\u20133.912) and preoperative CCRT (<jats:italic>p<\/jats:italic> = 0.003; relative risk = 2.861; 95% CI = 1.417\u20135.778) were identified as independent prognostic factors. The overall survival of the nonleakage group and the leakage group was 80.2% and 64.9%, respectively (<jats:italic>p<\/jats:italic> = 0.170). The 5\u2010year disease\u2010free survival rates were not significantly different between the nonleakage and leakage groups (78.1% vs. 65.9%, <jats:italic>p<\/jats:italic> = 0.166).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of anastomotic leakage after low anterior resection is relatively low. Male gender and preoperative CCRT were associated with increased risk for anastomotic leakage after rectal cancer surgery. No effect of anastomosis leakage on local recurrence was found in this series.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-007-9451-2","type":"journal-article","created":{"date-parts":[[2008,2,7]],"date-time":"2008-02-07T13:10:01Z","timestamp":1202389801000},"page":"1124-1129","source":"Crossref","is-referenced-by-count":145,"title":["Risk Factors and Clinical Outcome for Anastomotic Leakage After Total Mesorectal Excision for Rectal Cancer"],"prefix":"10.1002","volume":"32","author":[{"given":"Won\u2010Suk","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery Samsung Medical Center, Sungkyunkwan University School of Medicine 50 Irwon\u2010dong 135\u2010710 Gangnam\u2010gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Hyeon","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center, Sungkyunkwan University School of Medicine 50 Irwon\u2010dong 135\u2010710 Gangnam\u2010gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Nam","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center, Sungkyunkwan University School of Medicine 50 Irwon\u2010dong 135\u2010710 Gangnam\u2010gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae\u2010Ran","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center, Sungkyunkwan University School of Medicine 50 Irwon\u2010dong 135\u2010710 Gangnam\u2010gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center, Sungkyunkwan University School of Medicine 50 Irwon\u2010dong 135\u2010710 Gangnam\u2010gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong 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