{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:22:57Z","timestamp":1761708177201},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,3,13]],"date-time":"2008-03-13T00:00:00Z","timestamp":1205366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recently, somatic inactivating mutations in <jats:italic>HRPT2<\/jats:italic> have been reported in the majority of sporadic parathyroid carcinoma in primary hyperparathyroidism (HPT). Parafibromin is a tumor suppressor protein encoded by <jats:italic>HRPT2<\/jats:italic>, and loss of nuclear expression of parafibromin was found in approximately 70% of the carcinoma. In secondary HPT due to chronic kidney disease (CKD), parathyroid carcinoma is very rare and whether <jats:italic>HRPT2<\/jats:italic> plays a role in the carcinogenesis in these cases is not clear. We evaluated the expression of parafibromin in hemodialysis patients with distant metastatic parathyroid tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between June 1973 and December 2006, 2,142 patients underwent parathyroidectomy (PTx) for secondary HPT in our department. We encountered five (0.23%) patients with distant metastatic parathyroid tumors. We evaluated the immunohistochemistry for parafibromin in eight primary parathyroid glands removed from the neck at the initial operation and\/or at reoperation and seven distant metastatic tumors resected at reoperation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In only one lung metastatic parathyroid tumor, negative staining for parafibromin was detected. In the other three lung, two regional node, and one chest wall metastatic parathyroid tumor, parafibromin was strongly stained in the nuclei of the parathyroid cells. Among eight primary glands, except for one with weakly positive staining, the expression of parafibromin was detected diffusely and strongly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that the inactivating mutations and\/or allelic loss of the <jats:italic>HRPT2<\/jats:italic> gene may not play a major role in parathyroid carcinogenesis in secondary HPT due to CKD, but in these cases cancer development may be associated with a heterogeneous genetic disorder.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-007-9458-8","type":"journal-article","created":{"date-parts":[[2008,3,12]],"date-time":"2008-03-12T20:50:55Z","timestamp":1205355055000},"page":"815-821","source":"Crossref","is-referenced-by-count":26,"title":["Expression of Parafibromin in Distant Metastatic Parathyroid Tumors in Patients with Advanced Secondary Hyperparathyroidism Due to Chronic Kidney Disease"],"prefix":"10.1002","volume":"32","author":[{"given":"Yoshihiro","family":"Tominaga","sequence":"first","affiliation":[{"name":"Department of Transplant and Endocrine Surgery Nagoya Second Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyonori","family":"Tsuzuki","sequence":"additional","affiliation":[{"name":"Department of Pathology Nagoya Second Red Cross Hospital Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Transplant and Endocrine Surgery Nagoya Second Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Uno","sequence":"additional","affiliation":[{"name":"Department of Transplant and Endocrine Surgery Nagoya Second Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuhiko","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Transplant and Endocrine Surgery Nagoya Second Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syuichi","family":"Shimabukuro","sequence":"additional","affiliation":[{"name":"Department of Transplant and Endocrine Surgery Nagoya Second Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihiko","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Transplant and Endocrine Surgery Nagoya Second Red Cross Hospital 2\u20109 Myoken\u2010cho, Showa\u2010ku 4668650 Nagoya 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