{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:09:02Z","timestamp":1785798542120,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,3,12]],"date-time":"2008-03-12T00:00:00Z","timestamp":1205280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The risk of multiglandular disease (MGD) dictates the extent of exploration in patients with primary hyperparathyroidism (PHPT). Historically, young patients with PHPT were more likely to have MGD, but the existing literature is sparse and conflicting. We hypothesized that young adults (ages 16\u201340 years) without familial PHPT have a disease process similar to that in older patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 22\u2010year retrospective chart review was performed on patients who underwent neck exploration for PHPT at our tertiary care center. Altogether, 708 charts were reviewed for demographics, family history, laboratory values, operative findings, pathology, and outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As a group, young adults comprised 14.0% of the total population and were more likely to have preexisting familial disorders of PHPT (<jats:italic>p<\/jats:italic> &lt; 0.01), therapeutic failure (<jats:italic>p<\/jats:italic> &lt; 0.01), failure to identify an abnormal parathyroid at operation (<jats:italic>p<\/jats:italic> &lt; 0.01), and higher reoperative rates (<jats:italic>p<\/jats:italic> = 0.02); they were less likely to have single\u2010gland disease (<jats:italic>p<\/jats:italic> = 0.04). Young adults without a family history of the disease demonstrated no disease differences except for a higher rate of symptoms (<jats:italic>p<\/jats:italic> &lt; 0.01). Additional analysis found that patients with a family history of hypercalcemia, a sole family member with PHPT, or nephrolithiasis (\u201cpossible\u201d family history) were more likely to have MGD (relative risk 2.0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this largest single\u2010institution study of young adults with sporadic PHPT, we conclude that sporadic PHPT in young adults represents a disease entity similar to that in older patients, with no increased risk for MGD, and hence they can be managed with a similar surgical approach. Further studies are needed to assess the role of a \u201cpossible\u201d family history as a risk factor for MGD.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-008-9515-y","type":"journal-article","created":{"date-parts":[[2008,3,11]],"date-time":"2008-03-11T15:22:49Z","timestamp":1205248969000},"page":"1518-1524","source":"Crossref","is-referenced-by-count":17,"title":["Role for Limited Neck Exploration in Young Adults with Apparently Sporadic Primary Hyperparathyroidism"],"prefix":"10.1002","volume":"32","author":[{"given":"Laura A.","family":"Adam","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology and Endocrine Surgery University of Iowa Hospitals and Clinics 200 Hawkins Drive 52242 Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Iowa Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Calva\u2010Cerqueira","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology and Endocrine Surgery University of Iowa Hospitals and Clinics 200 Hawkins Drive 52242 Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Howe","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology and Endocrine Surgery University of Iowa Hospitals and Clinics 200 Hawkins Drive 52242 Iowa City IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geeta","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Surgical Oncology and Endocrine Surgery University of Iowa Hospitals and Clinics 200 Hawkins Drive 52242 Iowa City IA 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