{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:09:54Z","timestamp":1787062194523,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,5,8]],"date-time":"2008-05-08T00:00:00Z","timestamp":1210204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lithium is frequently used in the treatment of bipolar disease. Although lithium\u2010associated hyperparathyroidism (LAH) is well documented, reports concerning its pathologic findings are sparse. Because of a high\u2010reported incidence of multiglandular disease, focused exploration for LAH is controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From 1995 to 2007, data from 1207 consecutive patients who underwent concise parathyroid exploration for sporadic primary hyperparathyroidism (PHP) directed by quick intraoperative parathyroid hormone monitoring (QPTH) were reviewed to identify patients with LAH. Anatomic findings were determined. All patients had &gt;5\u00a0months of follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of LAH was 16\/1207 (1.3%). The rate of multiglandular disease was not higher in LAH: present in 25% (4\/16) patients with LAH and 12.3% (146\/1191) patients without LAH (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.13 Fisher two\u2010tailed test). Among 16 patients with LAH, 12 (75%) had a single adenoma. The use of QPTH allowed unilateral exploration in 8 of 12 patients with single adenoma. Parathyroid exploration resulted in durable biochemical cure for all 16 patients with LAH.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Multiglandular disease seems to be no more frequent in patients with LAH than in patients with primary hyperparathyroidism (PHP) without LAH. Patients with LAH can be safely and effectively managed with selective unilateral exploration directed by intraoperative PTH monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-008-9616-7","type":"journal-article","created":{"date-parts":[[2008,5,7]],"date-time":"2008-05-07T08:07:29Z","timestamp":1210147649000},"source":"Crossref","is-referenced-by-count":35,"title":["Appropriate Surgical Treatment of Lithium\u2010Associated Hyperparathyroidism"],"prefix":"10.1002","volume":"32","author":[{"given":"Evie","family":"Carchman","sequence":"first","affiliation":[{"name":"Department of General Surgery UPMC 200 Lothrop Street 15213 Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Ogilvie","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery UPMC Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Holst","sequence":"additional","affiliation":[{"name":"Department of Endocrinology UPMC Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Yim","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery UPMC Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Carty","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery UPMC Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,5,8]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"115","article-title":"The prevalence, mechanism and clinical significance of lithium\u2010induce hypercalcaemia","volume":"44","author":"McIntosh WB","year":"1987","journal-title":"Med Lab Sci"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(73)90846\u20105"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(76)92867\u20101"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP.12.1.54"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.9.2844"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem\u201052\u20105\u20101046"},{"key":"e_1_2_5_8_2","first-page":"96","article-title":"Lithium\u2010induced alterations in parathormone function in patients with bipolar disorder","volume":"11","author":"Turan MT","year":"2001","journal-title":"Bull Clin Psychopharm"},{"key":"e_1_2_5_9_2","first-page":"1061","article-title":"Lithium effects on dispersed bovine parathyroid cells grown in tissue culture","volume":"110","author":"McHenry CR","year":"1991","journal-title":"Surgery"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000120072.85692.a7"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP.7.4.323"},{"key":"e_1_2_5_12_2","first-page":"1","article-title":"Diagnosis and management of asymptomatic primary hyperparathyroidism. Indications for surgical treatment","volume":"8","author":"US Department of Health and Human Services","year":"1990","journal-title":"NIH consensus statement"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.09.006"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/106002809302700904"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.09.028"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102168.1999.00977.x"},{"key":"e_1_2_5_17_2","first-page":"363","article-title":"Surgical treatment of hyperparathyroidism using the quick parathyroid assay","volume":"15","author":"Stratmann SL","year":"2002","journal-title":"Proc (Bayl Univ Med Cent)"},{"key":"e_1_2_5_18_2","first-page":"91","article-title":"The role of intraoperative parathyroid hormone assay in the surgical management of hyperparathyroidism","volume":"78","author":"Romani AM","year":"2007","journal-title":"Ann Ital Chir"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102796.2004.01428.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2005.01.029"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039\u20106060(97)90215\u20104"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.128479"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010002\u20106824\u20104"},{"key":"e_1_2_5_24_2","first-page":"614","article-title":"Surgical management of lithium\u2010induced hypercalcemia","volume":"54","author":"Feldman MG","year":"1990","journal-title":"Conn Med"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00045391\u2010199709000\u201000007"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(77)90572\u20104"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102796.1996.28864000.x"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109343(02)01306\u20102"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100447.1982.tb06718.x"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026\u20100495(94)90017\u20105"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.07.019"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-008-9616-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-008-9616-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-008-9616-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T10:02:27Z","timestamp":1704880947000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-008-9616-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,8]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1007\/s00268-008-9616-7"],"URL":"https:\/\/doi.org\/10.1007\/s00268-008-9616-7","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,8]]},"article-number":"2195"}}