{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:18:55Z","timestamp":1765545535532},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,12,4]],"date-time":"2008-12-04T00:00:00Z","timestamp":1228348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Postoperative ileus, a common complication in patients after abdominal surgery, brings no benefit to the recovery of postoperative patients, and treatment targeted at restoring gastrointestinal motility may shorten the hospital stay. Studies have shown that escin accelerates gastrointestinal transit in mice and improves gastrointestinal motility in patients after abdominal surgery. A pilot study of escin\u2019s effect on the recovery of gastrointestinal motility was conducted in colorectal cancer patients in anticipation of a multiple\u2010center randomized controlled trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 72 postoperative colorectal cancer patients were randomly assigned to four parallel groups on the basis of sealed envelopes\u2014escin 5\u00a0mg group (E5\u00a0mg), escin 15\u00a0mg group (E15\u00a0mg), escin 25\u00a0mg group (E25\u00a0mg), and placebo group\u2014with 18 patients in each group. Escin or placebo was diluted in 500\u00a0ml 5% dextrose injection, which was given once daily through the subclavian vein. The first injection took place 6 h after completion of the surgery. The treatment continued for 7\u00a0days or stopped at the time of the patient\u2019s first bowel movement. Time to recovery of passage of gas (TRPG), time to recovery of gastrointestinal sounds (TRGS), and time to recovery of bowel movements (TRBM) were recorded to evaluate the efficacy of escin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The TRPGs of the three escin treatment groups were 76.78 + 28.81 h (E5\u00a0mg), 72.06 + 14.65 h (E15\u00a0mg), and 65.50 + 26.70 h (E25\u00a0mg), respectively, with differences of 6.03 \u00b1 7.64 h (<jats:italic>p<\/jats:italic> = 0.436; E5\u00a0mg), 10.75 \u00b1 4.92 h (<jats:italic>p<\/jats:italic> = 0.036; E15\u00a0mg), and 17.31 \u00b1 7.20 h (<jats:italic>p<\/jats:italic> = 0.022; E25\u00a0mg) compared with the placebo group. The TRGSs of the three escin treatment groups were 45.28 \u00b1 26.15 h (E5\u00a0mg), 41.22 \u00b1 16.98 h (E15\u00a0mg), and 40.33 \u00b1 14.09 h (E25\u00a0mg), respectively, with differences of 4.33 \u00b1 7.12 h (<jats:italic>p<\/jats:italic> = 0.547; E5\u00a0mg), 8.39 \u00b1 5.36 h (<jats:italic>p<\/jats:italic> = 0.127; E15\u00a0mg), and 9.28 \u00b1 4.87 h (<jats:italic>p<\/jats:italic> = 0.065; E25\u00a0mg) compared with the placebo group. The TRBMs of the three escin treatment groups were 89.25 \u00b1 23.77 h (E5\u00a0mg), 84.83 \u00b1 27.91 h (E15\u00a0mg), and 84.44 \u00b1 19.74 h (E25\u00a0mg), respectively, with differences of 19.03 \u00b1 10.13 h (<jats:italic>p<\/jats:italic> = 0.069; E5\u00a0mg), 23.44 \u00b1 10.70 h (<jats:italic>p<\/jats:italic> = 0.035; E15\u00a0mg), and 23.83 \u00b1 9.63 h (<jats:italic>p<\/jats:italic> = 0.019; E25\u00a0mg) compared with the placebo group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this pilot Postoperative Ileus Study of Escin (PISE) showed that escin can shorten the time to recovery of gastrointestinal motility in cancer patients after colorectal surgery.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-008-9816-1","type":"journal-article","created":{"date-parts":[[2008,12,3]],"date-time":"2008-12-03T20:51:06Z","timestamp":1228337466000},"page":"348-354","source":"Crossref","is-referenced-by-count":21,"title":["Pilot Postoperative 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