{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:57:54Z","timestamp":1761807474641,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,11,21]],"date-time":"2008-11-21T00:00:00Z","timestamp":1227225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rectal cancer is a lifestyle\u2010related illness with an increasing incidence in all developing countries in the last decade. Abdominoperineal resection (APR) offers a good oncologic clearance for low rectal cancer. The remaining controversies surrounding APR, as it is performed in a tertiary center in Nigeria, involve defining the role the operation plays in the management of existing rectal problems and determining what outcomes can be expected. The present study was aimed at examining the surgical outcomes of APR for low rectal cancers in a Nigerian tertiary institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This single\u2010institution, retrospective, descriptive study analyzed APR rate, patient sex and age, subsite involvement, the diagnostic process, follow\u2010up, and survival patterns after treatment of low rectal cancers. The study was conducted at Obafemi Awolowo University Teaching Hospital Complex Ile\u2010Ife, Nigeria, between January 1989 and December 2007.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the 18\u2010year period, 36 patients underwent APR. This accounts for 24.0% of all patients that had low rectal cancer. The age of the patients ranged from 29 years to 74 years (median: 58.9 years). Most of the patients were 60 years of age or older, and the majority were women (55.9%). The median duration of symptoms was 12\u00a0months, and all patients sought medical care for bleeding per rectum. Close to 80% of patients had advanced disease at presentation. Postoperatively, 17 patients (50%) had at least one complication and one patient (2.9%) died. Four (11.8%) patients had recurrence of the tumor, and in every case, recurrence occurred within the first year after operation. Operative blood loss (<jats:italic>p<\/jats:italic> = 0.006), degree of differentiation of the tumor (<jats:italic>p<\/jats:italic> = 0.011), distance from the anal verge (<jats:italic>p<\/jats:italic> = 0.033), and operative stage (<jats:italic>p<\/jats:italic> = 0.005) were found to significantly affect the outcome of treatment for the patients who underwent APR. The operative stage similarly affected the survival of patients (Mantel Cox = 0.026).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the advanced disease of our patients, the outcome of management appears to be comparable with results reported from other centers.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-008-9817-0","type":"journal-article","created":{"date-parts":[[2008,11,20]],"date-time":"2008-11-20T14:02:40Z","timestamp":1227189760000},"source":"Crossref","is-referenced-by-count":8,"title":["Surgical Outcome of Abdominoperineal Resection for Low Rectal Cancer in a Nigerian Tertiary Institution"],"prefix":"10.1002","volume":"33","author":[{"given":"Olusegun I.","family":"Alatise","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, College of Health Sciences Obafemi Awolowo University Ile\u2010Ife Nigeria"},{"name":"Department of Surgery Obafemi Awolowo University Teaching Hospital Complex PMB 5538 Ile\u2010Ife Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oladejo O.","family":"Lawal","sequence":"additional","affiliation":[{"name":"Department of Surgery Obafemi Awolowo University Teaching Hospital Complex PMB 5538 Ile\u2010Ife Nigeria"},{"name":"Department of Surgery, College of Health Sciences Obafemi Awolowo University Ile\u2010Ife Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulrasheed K.","family":"Adesunkanmi","sequence":"additional","affiliation":[{"name":"Department of Surgery Obafemi Awolowo University Teaching Hospital Complex PMB 5538 Ile\u2010Ife Nigeria"},{"name":"Department of Surgery, College of Health Sciences Obafemi Awolowo University Ile\u2010Ife Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen A.","family":"Osasan","sequence":"additional","affiliation":[{"name":"Department of Morbid Anatomy Obafemi Awolowo University Teaching Hospital Complex PMB 5538 Ile\u2010Ife Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,11,21]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.21.6.361"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20101318.2005.00913.x"},{"key":"e_1_2_5_4_2","first-page":"838","article-title":"Contemporary indications for and early outcomes of abdominoperineal Resection","volume":"71","author":"Murrell ZA","year":"2005","journal-title":"Am Surg"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140\u20106736(90)92631\u2010Q"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00384\u2010002\u20100474\u20108"},{"key":"e_1_2_5_7_2","first-page":"517","article-title":"Experience with the Russian suture gun for rectal anastomosis","volume":"148","author":"Goligher JC","year":"1970","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350\u2010004\u20106325\u20107"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02054976"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-509X.12680"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2005.09.001"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(05)70422\u20108"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350\u2010004\u20106401\u2010z"},{"key":"e_1_2_5_14_2","first-page":"689","article-title":"Colorectal carcinoma\u07dda new threat to black patients? 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