{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:17:24Z","timestamp":1791778644262,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,1,24]],"date-time":"2009-01-24T00:00:00Z","timestamp":1232755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this study was to evaluate the long\u2010term outcomes of a single institution, Hospital S\u00edrio\u2010Libanes in S\u00e3o Paulo, Brazil, regarding the treatment of peritoneal carcinomatosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between October 2002 and October 2006, 46 consecutive patients were treated with radical cytoreduction and hyperthermic peritoneal chemotherapy. There were 21 patients with peritoneal surface malignancy (PSM) from colorectal origin (among whom 8 had an appendiceal primary), 15 with ovarian carcinomas, 2 with primary peritoneal mesotheliomas, and 8 with other cancers. The median age was 49 years (range 18\u201377 years). All patients were followed for a median of 20\u00a0months. Demographic data, tumor histology, the peritoneal carcinomatosis index (PCI), operative procedures (extension of resection, lymphadenectomy), and hyperthermic intraperitoneal chemotherapy (HIPEC) characteristics (drugs, temperature, duration) were prospectively recorded. Perioperative mortality and morbidity and the long\u2010term outcome were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete cytoreduction was achieved in 45 patients. The median PCI was 11, and the mean operating time was 17 h. There were no procedure\u2010related deaths, but major morbidity was observed in 52% and included fistulas, abscesses, and hematologic complications. The overall Kaplan\u2013Meier 4\u2010year estimated survival was 56%. Among patients with PSM from colorectal carcinoma, the estimated 3\u2010year survival was 70%. Nine (42%) patients had a recurrence, three with peritoneal disease. The median disease\u2010free\u2010interval was 16\u00a0months. The ovarian cancer patients had an estimated 4\u2010year survival rate of 75% and median disease\u2010free survival duration of 21\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cytoreductive surgery with HIPEC may improve survival of selected patients with peritoneal carcinomatosis, with acceptable morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-008-9880-6","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T15:40:52Z","timestamp":1232725252000},"page":"835-839","source":"Crossref","is-referenced-by-count":9,"title":["Peritonectomy for Peritoneal Carcinomatosis: Long\u2010Term Outcomes from a Single Brazilian Institution"],"prefix":"10.1002","volume":"33","author":[{"given":"Eduardo","family":"Akaishi","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology S\u00e3o Paulo University School of Medicine (LIM62); Centro de Oncologia, Hospital Sirio Libanes Rua Dona Adma Jafet, 91 CEP 01308\u2010050 S\u00e3o Paulo SP Brazil"},{"name":"Rua S\u00e3o Firmo 100 S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology S\u00e3o Paulo University School of Medicine (LIM62); Centro de Oncologia, Hospital Sirio Libanes Rua Dona Adma Jafet, 91 CEP 01308\u2010050 S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology S\u00e3o Paulo University School of Medicine (LIM62); Centro de Oncologia, Hospital Sirio Libanes Rua Dona Adma Jafet, 91 CEP 01308\u2010050 S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Mizumoto","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology S\u00e3o Paulo University School of Medicine (LIM62); Centro de Oncologia, Hospital Sirio Libanes S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederico P.","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology S\u00e3o Paulo University School of Medicine (LIM62); Centro de Oncologia, Hospital Sirio Libanes S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Carlos","family":"Buzaid","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology S\u00e3o Paulo University School of Medicine (LIM62); Centro de Oncologia, Hospital Sirio Libanes S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo M.","family":"Hoff","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology S\u00e3o Paulo University School of Medicine (LIM62); Centro de Oncologia, Hospital Sirio Libanes S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199502000-00002"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.6.983"},{"key":"e_1_2_6_4_2","first-page":"5790","article-title":"Early postoperative intraperitoneal chemotherapy as an adjuvant therapy to surgery for peritoneal carcinomatosis from gastrointestinal cancer: pharmacological studies","volume":"50","author":"Sugarbaker PH","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277\u20105379(90)90137\u2010I"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421\u2010198806000\u201000013"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u20106\u2010162"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10434\u2010999\u20100727\u20107"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.06.139"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100142(19960615)77:12<2622::AID\u2010CNCR28>3.0.CO;2\u2010T"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199501000\u201000004"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1247-5_24"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10434\u2010999\u20100790\u20100"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.187"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh186"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hye088"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102168.2000.01571.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anchir.2004.07.002"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/000313480006600607"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.1.26"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(20010701)92:1<71::AID\u2010CNCR1293>3.0.CO;2\u20109"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(20000601)88:11<2512::AID\u2010CNCR12>3.0.CO;2\u2010J"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2000.1095"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096\u20109098(200005)74:1<41::AID\u2010JSO10>3.0.CO;2\u2010R"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20013"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4516"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.2000.1033"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2003.03.067"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-008-9880-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-008-9880-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-008-9880-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T23:13:11Z","timestamp":1704928391000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-008-9880-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,24]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1007\/s00268-008-9880-6"],"URL":"https:\/\/doi.org\/10.1007\/s00268-008-9880-6","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,24]]}}}